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Herbal Remedies Natural Health Newsletter, December 2005, Issue 254


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Herbal Remedies December 2005
Natural Health Newsletter Issue 254
Sponsored by www.HerbalRemedies.com
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Issue Editor - Heather Bowman
Herbs - Vitamins - Minerals - Magnetics - Candles - Aromatherapy - Holiday Gifts - Bath & Beauty - Essential Oils - Condition & Ailment Guide - Women's Health - Men's Health - Weight Loss - Health Books
  • 20 Supplements for a Healthy Holiday Season, Part 1 - Click here for full story.

  • 20 Supplements for a Healthy Holiday Season, Part 2 - Click here for full story.

  • Selenium: The New Arthritis Supplement? - Click here for full story.

  • Another Use for Cranberry: Helping Prevent Lung, Colon, and Adult Cancer - Click here for full story.

  • Study Discovers How Vitamin E Helps Prevent Prostate Cancer - Click here for full story.

    Herbal Remedies has 3 partner sites be sure to check them out as well: Magnetic Therapy Magnets , and Natural Hair Loss Remedies

    Product Spotlight - Hoodia Dynamic Health's Pounds Away Liquid Detox Weight Loss Formula combines the delicious taste of Mangosteen Juice with Hoodia. You can enjoy sipping it pure or mixed with your favorite beverage. Fast & Easy Liquid Weight Loss Program.

    Need stocking stuffer ideas or just any ideas for natural gifts under $20 then look no further then your complete Herbal Remedy Super Store!

    In order to show customers how much we appeciate your business and celebration of our 5th year of quality service we are holding our Customer Appreciation Month

    Available now for downloading our Herbal Remedies Catalog .

    Current Event News: Support the Health Freedom Protection Act
    Reprinted with permission from Citizens for Health, www.citizens.org, November 15, 2005

    One can’t help but marvel at the simplicity and inherent healthfulness of food-based remedies. Imagine how much healthier we would be if, before leaping to purchase synthetic prescription drugs, we turned to foods and natural remedies as the first step toward solving our health problems. Imagine how much money we would save; imagine how much money the U.S. government and employers would save.

    Unfortunately, consumers in the U.S. are not getting all the information they need to make safe, natural health choices.

    The FDA’s approval process for informational labeling of food-based health claims has been so slow and uncertain that very little meaningful health information is making its way to food and dietary supplement consumers. In two years, only nine products have received approval to be labeled with qualified health claims, and no applications have yet been received by the FDA this year. The FDA’s bottlenecking of qualified health claims for foods and dietary supplements withholds critical health and disease prevention information from us, the American public.

    WE CAN CHANGE THE LAW

    A bill has been introduced into the U.S. House of Representatives that would give consumers access to truthful, non-misleading health information. The Health Freedom Protection Act, H.R. 4282, was introduced in the U.S. House on Wednesday, November 9th, 2005. The purpose of this bill is to amend the Food, Drug and Cosmetic Act to ensure that:

    1. Accurate health claims are not suppressed

    2. Consumers are given truthful and full information about the science supporting the health-enhancing effects of foods and dietary supplements (including scientific evidence that foods, dietary supplements and dietary ingredients may provide benefits relating to the cure, mitigation, treatment and prevention of disease (not drug effects).

    3. The FDA honors the intent of the Congress to not censor accurate health claims

    Passage of The Health Freedom Protection Act, H.R. 4282, would yield more health information on the foods and supplements we buy, potentially cutting our drug costs by educating us about natural alternatives.

    H.R. 4282 would not encourage companies to provide false hope but, on the contrary, would instead finally provide consumers more science-based information rather than less. H.R. 4282 would not weaken the FDA's and FTC's enforcement powers but would instead strengthen consumers’ access to truthful, science-supported and non-misleading health information. H.R. 4282 would not take away anything but would instead give consumers the breadth and depth of information that is true to the spirit and intent of the laws which support and defend consumers’ rights to science-supported health information.

    Click here to send a letter to your representative and encourage them to support H.R. 4282

    Please don't settle for scientific censorship. Stand up for your First Amendment rights by sending a message to your Representative telling them you want the Health Freedom Protection Act, H.R. 4282, passed into law.

    In Health,
    Ana Micka
    President of Citizens for Health

    To make your online shopping even more convenient for you we have a vast selection of products priced with you in mind in our RED HOT SALE ITEMS

    QUESTIONS AND ANSWERS

    Q:
    Subject: I would like to know if there is any proof that placing a few drops of rosemary oil around the hair-line can prevent lice from attatching itself to ones hair?
    Many thanks

    A:
    Dear Customer,
    From what I have researched on the internet I found that a combonation of essential oils helps to keep lice away. Here is a list of what they are: Pure Olive Oil as a carrier or Coconut Oil also as a carrier, then Lavender, Eucalyptus, Rosemary, Tea Tree Oil and Pepperemint Oil. You can add these essential oils to any shampoo or conditioner containing coconut oil or olive oil. Please check out our fine selection of Essential Oils
    Thank you for your interest in Herbal Remedies.com and the opportunity to serve you.
    Lisa
    * The statements regarding these products have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. The information on this Web site or in emails is designed for educational purposes only. It is not intended to be a substitute for informed medical advice or care. You should not use this information to diagnose or treat any health problems or illnesses without consulting your pediatrician or family doctor. Please consult a doctor with any questions or concerns you might have regarding you or your child's condition. Informational material and representations have been provided by the manufacturers of the listed products.

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20 Supplements for a Healthy Holiday Season, Part 1

By Jayson Kroner, C.S.N.

Note: This is a two-part article on winter wellness. Part 1 covers Stress and Cold & Flu. Part 2 will cover Digestive Support, Weight Loss, and Energy.

Faster than you can scream “I was already waiting for that parking spot!” the holidays will be upon us. And while this fast-approaching time of year can be one of reflection, family and celebration, let’s not forget that we’re still human.

Remarkably, far too many of us unwillingly subject ourselves to a seemingly inhuman holiday to-do list. What’s even more remarkable is that this list actually seems to grow with each passing year. Crowded shopping malls, unexplainable overeating, mind-numbing family stories, and deadly flu strains can leave even the most health-savvy individual physically, emotionally and nutritionally drained.

Don’t fret. This business of science and nutrition is a remarkable one, and has afforded us with a wealth of supplements that can help support the five major areas of vulnerability during the holiday season. Let’s examine each, individually.

STRESS

Phosphatidyl Serine
This potent phospholipid is a vital component of cognitive health, and plays an important role in the billions of neurotransmissions that take place each second within the body. It has been shown to help improve the quality of electrical impulses, making it much more possible to juggle the hundreds of tasks that surface during the holidays.(1)

GABA
As joyous as they are, the holidays have the uncanny ability to send our brains into a decision making frenzy. GABA is a naturally occurring amino acid that works by preventing neurotransmitters from over firing during high periods of stress and anxiety.(2)

St. John’s Wort
The extracts of this summer perennial contain hypericin – a natural pigment that has been shown to help balance mood by encouraging the brain’s natural production and activity of serotonin. Many have also used it to help overcome brief stints of insomnia and restlessness, as well.(3)

Omega-3 Fish Oil
A now famous 1999 Harvard study was among the very fist to conclude that the EPA and DHA compounds in Omega-3 essential fatty acids seem to have a very positive impact on how well the body handles many form stress and anxiety. Their beneficial effects are in no way limited to stress, though. Fish oil plays a number of roles within the body that can influence holiday wellness, and year-round health.(4)

COLD and FLU

Olive Leaf
Nothing can spoil the spirit of the season faster than an untimely bout with the flu or common cold. The leaves of Olive trees (Olea Europaea) trees contain high concentrations of oleuropeins. These powerful compounds help eliminate foreign microbes while promoting a responsive immune system.(5)

Zinc Lozenges
When taken at the first sign of a cold or flu, zinc lozenges shower the throat with a potent layer of immune-enhancing compounds. This creates an environment that is unfavorable to many of microbes and viral infections that commonly wreak havoc during the cold, winter months.(6)

Ester-C with Bioflavonoids
Ester C is a powerful free radical fighter that’s been used by millions to protect cells from the damaging effects of oxidation. In addition, it’s essential to virtually every aspect of human life. When coupled with bioflavonoids, the synergistic effects help increase its overall effectiveness and bioavailability.(7)

Mushroom extracts
Medicinal mushroom extracts such as Shiitake, Reishi and Maitake contain some of the most powerful immune-boosting compounds available - 1,3 beta glucans. These naturally-occurring cell guardians have been shown to help support innate and adaptive immunity by stimulating the production of NK (natural killer) cells & white blood cells.(8)

Check out Part 2 of this article on Digestive Support, Weight Loss, and Energy.
References

1 Crook TH, et al. Effects of Phosphatidylserine in age-associated memory impairment. Journal of Neurology 1991 May;41(5):644-649

2 Braverman E, Pfieffer C. The Healing Nutrients Within. In Facts, Findings and New Research on Amino Acids. New Canaan, CT: Keats Publishing, 1987

3 Laakmann, G.; Schule,C.; Baghai, T., and Kieser, M. St. John's wort in mild to moderate depression: the relevance of hyperforin for the clinical efficacy. Pharmacopsychiatry. 1998 Jun; 31 Suppl 1:54-9

4 Stoll, Andrew L., et al. Omega 3 fatty acids in bipolar disorder. Archives of General Psychiatry, Vol. 56, May 1999, pp. 407-12 and pp. 415-16

5 Balch, James, The Super Antioxidants, 1998, M. Evans and Company Publishing

6 Godfrey JC, Conant Sloane B, Smith DS, et al. Zinc gluconate and the common cold: A controlled clinical study. J Int Med Res 1992;20:234-46

7 Enstrom JE, Kanim LE, Klein MA. Vitamin C intake and mortality among a sample of the United States population. Epidemiology. 1992; 3:194-202

8 Breene W. M. 1989. Nutritional & Medicinal Value of Exotic Mushrooms. Shiitake Mushrooms. The Proceeding of a National Symposium & Trade Show University of Minnesota 100-102

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20 Supplements for a Healthy Holiday Season, Part 2

By Jayson Kroner, C.S.N.

Note: This is a two-part article on winter wellness. Part 1 covered Stress and Cold & Flu. Part 2 covers Digestive Support, Weight Loss, and Energy.

DIGESTIVE SUPPORT

Psyllium
During the holidays, the digestive system is subject to foods and other goodies that come only once a year. Sadly, most of these holiday treats lack fiber, making digestion an arduous task. Psyllium is an effective natural source of soluble fiber with remarkable bulking abilities. When taken with plenty of water, it can serve as a smart way to ensure that there’s always room for one last bite.(1)

Milk Thistle
A month of high-powered egg nog, champagne toasts, holiday parties and new years celebrations can take a serious toll on the efficacy of the liver. Milk thistle is a safe herbal extract that has been used for thousands of years to help cleanse and purify the liver, while increasing the flow of bile for healthy digestion.(2)

Acidophilus
Mere mention of the word bacteria can make most people cringe. However, it’s important to remember the body relies on many “friendly” bacteria to help with digestion, metabolism and gastrointestinal infections. Acidophilus is a probiotic that has been shown to support optimal digestion.(3)

Digestive Enzymes
It’s bad enough that a large percentage of Americans suffer from some form of enzymatic deficiency. When you factor in holiday overeating, the need for additional digestive enzymes becomes even more important. Look for a formula that contains a versatile mix of enzymes, clearly stating its “active units” and milligrams per serving.(4)

WEIGHT LOSS

CLA (Conjugated linoleic acid)
Since its introduction in the mid-1990’s, CLA has been used by millions to help support a healthy physique. A number of clinical studies have demonstrated its ability to help preserve lean muscle tissues while breaking down stored fat that can then be used for energy and metabolism.(5)

Kelp
Before the body can even begin to metabolize those extra holiday calories, it must have the right mix of nutrients present in order to produce thyroid hormones. Iodine is one of the most important, and mandatory for the production of T3 and T4 thyroid hormones. Kelp is an excellent source of iodine, and a smart way to support a healthy thyroid.(6)

Citrimax®
Hydroxy-citric acid (HCA) provides a natural, non-stimulating thermogenic effect that has helped scores of physique-minded individuals reach their dietary goals. Many users take it with Chromium and Kelp to increase its effectiveness.(7)

Relora®
By now, it’s safe to assume that most of us have seen at least one ad on TV that talks about the stress hormone cortisol. Relora® is a patented proprietary blend of standardized extracts of magnolia officialis and phellodendron amurense that has been shown to induce relaxation, and prevent the release of this nasty stress hormone.(8)

ENERGY

Multiple vitamin and mineral formula
Ok, so taking a multiple won’t send you bouncing off the walls. But make no mistake – a good multiple can provide the nutritional foundation essential to thousands of biological actions, including cellular energy production. (This comes in very handy when chasing kids through a toy store).

B-Complex Vitamins
The B family of vitamins plays an active role in virtually every aspect of life, and is of considerable importance for anyone who lacks energy during the hustle and bustle of the busy holiday season. Look for a “stress” formula for added support.

CoQ10
This ultra-beneficial substance is present in every living cell, and essential to immune function, heart health, tissue protection and cellular energy production. It’s widely considered one of the best supplements for the cardiovascular system based on its ability to support high-energy organs.(9)

L-Carnitine
L-Carnitine is an amino acid-like substance that has become a true legend among dietary supplements. Its primary role is to escort long-chain fatty acids into the “factory” region of the cell. From there, they can be converted into energy that the body can use for metabolism, or just running last-minute holiday errands.(10)

In conclusion...
If you’re like most warm-blooded Americans, you probably hold the holiday season close to that love-hate section of your heart. But in spite of the time spent with loved ones, self-justified midnight cookie benders and the endless spectrum of lights that fill hearts, homes and horizons, it’s dire to keep one thing in mind. A commitment to sound winter wellness can make every toast, blessing and moment of reflection so much more enjoyable. So this year, before you give even one gift to a loved one, reward yourself with one of immeasurable value - the gift of good health. Now, and all year long.

Happy holidays!

References:

1 Davidson MH, Maki KC, Kong JC, et al. Long-term effects of consuming foods containing psyllium seed husk on serum lipids in subjects with hypercholesterolemia. Am Jour of Clin Nut. 1998;67:367-376.

2 Pares A, Planas R, Torres M, et al. Effects of silymarin in alcoholic patients with cirrhosis of the liver: results of a controlled, double-blind, randomized and multicenter trial. J Hepatol. 1998;28:615–621.

3 Thomas MR, Litin SC, Osmon DR, et al. Lack of effect of Lactobacillus GG on antibiotic-associated diarrhea: a randomized, placebo-controlled trial. Mayo Clin Proc. 2001;76:883–889.

4 Dahlqvist, A., The role of enzymes in the digestive tract. Prog Clin Biol Res, 1981. 77: p. 883-91.

5 Blankson H, Stakkestad JA, Fagertun H, et al. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J Nutr. 2000;130:2943–2948.

6 Clark MD CD, Bassett MD B, Burge MD MR. Effects of kelp supplementation on thyroid function in euthyroid subjects. Endocr Pract. 2003;9:363-9

7 Heymsfield SB, Allison DB, Vasselli JR, et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA. 1998;280:1596–1600.

8 Chambliss, W, Ph.D. A placebo controlled pilot study on the effects of Relora® capsules in the management of stress. 2005

9 Khatta M, Alexander BS, Krichten CM, et al. The effect of coenzyme Q10 in patients with congestive heart failure. Ann Intern Med. 2000;132:636-640.

10 Heinonen OJ. Carnitine and physical exercise. Sports Med. 1996;22:109–132

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Selenium: The New Arthritis Supplement?

By Greg Arnold, DC, CSCS, November 14, 2005

Arthritis limits everyday activities for 16 million Americans, results in 750,000 hospitalizations and costs our healthcare system over $51 billion each year. The Centers for Disease Control estimate that the number of people aged 65 or older with arthritis is projected to more than double, from 15.7 million in 2002 to 33.3 million in 2030.(1)

When it comes to osteoarthritis, the two most popular nutritional supplements to help both treat and prevent OA are glucosamine combined with chondroitin (2),(3) with recent research finding that “glucosamine sulfate may be effective and safe in delaying the progression and improving the symptoms of knee (arthritis)“.(4)

Now a new study presented at the American College of Rheumatology 2005 Annual Conference in San Diego(5) has re-introduced the possible use of a mineral to help treat OA: selenium .

Although only required in small amounts, Selenium is essential to health by being a component of important antioxidant enzymes called selenoproteins.(6) These enzymes help protect our cells from free radicals that contribute to the development of chronic diseases such as cancer and heart disease.(7) Selenoproteins also help regulate thyroid function and play a role in the immune system.(8) Plant foods are the major dietary sources of selenium in most countries throughout the world Following up on a 2002 study that found selenium helps prevent joint breakdown in OA,(9) researchers studied selenium intake on 940 participants. They found that those in the highest selenium group had only about half the chance of severe osteoarthritis or disease in both knees, with the association being even stronger in African-Americans and women.

Although the researchers admit they do not know just how selenium inhibits the progression of osteoarthritis , the researchers concluded that “there appears to be a clear relationship between selenium and osteoarthritis.”

Greg Arnold is a Chiropractic Physician practicing in Danville, CA. You can contact Dr. Arnold directly by emailing him at mailto:ChiroDocPSUalum@msn.com or visiting his website www.CompleteChiropracticHealthcare.com

Reference:

1 “Targeting Arthritis: Reducing Disability for 43 Million Americans” posted on the CDC Website www.cdc.gov/nccdphp/aag/aag_arthritis.htm

2 Towheed, T. E., L. Maxwell, et al. (2005). "Glucosamine therapy for treating osteoarthritis." Cochrane Database Syst Rev(2): CD002946.

3 Chalmers, R. (2005). "Managing osteoarthritis of the knee: glucosamine-chondroitin should be prescribed by doctors." Bmj 330(7492): 673.

4 Poolsup, N., C. Suthisisang, et al. (2005). "Glucosamine long-term treatment and the progression of knee osteoarthritis: systematic review of randomized controlled trials." Ann Pharmacother 39(6): 1080-7.

5 American College of Rheumatology 2005 Annual Conference – San Diego, CA www.rheumatology.org/annual/index.asp

6 “Dietary Supplement Fact Sheet: Selenium” posted on the Office of Dietary Supplements Website http://ods.od.nih.gov/factsheets/selenium.asp

7 Goldhaber SB. Trace element risk assessment: essentiality vs. toxicity. Regulatory Toxicology and Pharmacology. 2003;38:232-42.

8 McKenzie RC, Rafferty TS, Beckett GJ. Selenium: an essential element for immune function. Immunol Today 1998;19:342-5.

9 Kurz, B., B. Jost, et al. (2002). "Dietary vitamins and selenium diminish the development of mechanically induced osteoarthritis and increase the expression of antioxidative enzymes in the knee joint of STR/1N mice." Osteoarthritis Cartilage 10(2): 119-26.

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Another Use for Cranberry: Helping Prevent Lung, Colon, and Adult Cancer

By Greg Arnold, DC, CSCS, October 31, 2005, abstracted from “MALDI-TOF MS characterization of proanthocyanidins from cranberry fruit (Vaccinium macrocarpon) that inhibit tumor cell growth and matrix metalloproteinase expression in vitro” published online October 17, 2005 in the Journal of the Science of Food and Agriculture

Public interest in the North American cranberry as a functional food is increasing, due to a variety of potential health benefits. The most prominent of these benefits is an ability to help prevent the growth of the E. coli bacteria that are responsible for urinary tract infections.(1)

Cranberries contain high amounts of antioxidants called flavonols, anthocyanins, and proanthocyanins, compared to other fruit.(2) Research has found that these particular antioxidants help prevent oxidative processes including low-density lipoprotein oxidation(3, 4) and also decrease oxidative damage to nerves after a stroke.(5)

A new study(6) has found that cranberry antioxidants may help prevent a number of cancers namely lung cancer, adult leukemia (called ‘chronic myelogenous leukemia’), and colon cancer. In the study, cranberry extract was found to stop cell growth in three different cell lines, namely H460 lung, HT-29 colon and K562 leukemia cell lines. Researchers found that cranberry antioxidants inhibit lung, colon, and leukemia cell lines, but they are not as effective against breast cancer(7) as grape seed extract.(8)

Nevertheless, researchers were convinced of the anti-cancer benefits of cranberries, concluding that “(antioxidants in) cranberries…inhibit the proliferation of H460 lung, HT-29 colon and K562 leukemia cell lines.”

Greg Arnold is a Chiropractic Physician practicing in Danville, CA. You can contact Dr. Arnold directly by emailing him at mailto:ChiroDocPSUalum@msn.com or visiting his website www.CompleteChiropracticHealthcare.com

Reference:

1 Howell A. Inhibition of adherence of P-fimbricated Escherischia coli to uroepithelial-cell surfaces by proanthocyanidin extracts from cranberries. N Engl J Med 339: 1085-1086 (1998)

2 Vinson JA. Phenol antioxidant quantity and quality in foods: Fruits. J Agric Food Chem 49: 5315-5321 (2001)

3 Yan X. Antioxidant activities and antitumor screening of extracts from cranberry fruit (Vaccinium macrocarpon). J Agric Food Chem 20: 5844-5849 (2002)

4 Porter ML. Cranberry proanthocyanidins associate with low-density lipoprotein and inhibit in vitro Cu2+-induced oxidation. J Sci Food Agric 81: 1306-1313 (2001)

5 Neto CC. Cranberry phenolics: effects on oxidative processes, neuron cell death and tumor cell growth, in Symposium Series on Phenolics in Foods and Natural Health Products, ed. by Ho C-T and Shahidi F . ACS Books, Washington, DC, pp. 271-282 (2005)

6 Neto CC. MALDI-TOF MS characterization of proanthocyanidins from cranberry fruit (Vaccinium macrocarpon) that inhibit tumor cell growth and matrix metalloproteinase expression in vitro (p n/a). Published Online: 17 Oct 2005 Journal of the Science of Food and Agriculture. DOI: 10.1002/jsfa.2347

7 Seeram NP, Adams LS, Hardy ML and Heber D, Total cranberry extract versus its phytochemical constituents: antiproliferative and synergistic effects against human tumor cell lines. J Agric Food Chem 52: 2512-2517 (2004)

8 Ye X, Krohn RL, Liu W, Joshi SS, Kuszynski CA, McGinn TR, Bagchi M, Preuss HG, Shohs SJ and Bagchi D, The cytotoxic effects of a novel IH636 grape seed proanthocyanidin extract on cultured human cancer cells. Mol Cell Biochem 196: 99-108

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Study Discovers How Vitamin E Helps Prevent Prostate Cancer

By Greg Arnold, DC, CSCS, November 10, 2005, abstracted from “Tocopherol-Associated Protein Suppresses Prostate Cancer Cell Growth by Inhibition of the Phosphoinositide 3-Kinase Pathway” in the November 1, 2005 issue of Cancer Research

After a turbulent couple of weeks in early 2005 where its healthful effects were questioned,(1, 2) vitamin E has maintained its reputation as a vitally important antioxidant in the role of our health. These healthful properties of vitamin E lie in one type of antioxidant found in vitamin E, called tocopherols. Research has found that tocopherols help treat menstrual problems,(3) protect against Alzheimer Disease ,(4) prostate cancer ,(5) Lou Gehrig Disease (6) and even help prevent heart-related deaths in women.(7)

Despite all of this research, the exact mechanism by which tocopherols exert these effects is little-known. Other antioxidants present in full-spectrum vitamin E complexes are called tocotrienols. These antioxidants help minimize brain damage from strokes(8) by protecting our nerves against free radical damage.(9, 10, 11)

Now a new study(11) has found one way that vitamin E helps protect us against cancer, specifically prostate cancer.

Prostate cancer is the second leading cause of cancer deaths after lung cancer in American men.(12) Age, ethnic origin and a family history have all been found to increase prostate cancer risk. A recent NOW Foods article also pointed to processed foods as a significant cause of prostate cancer.

In the study, researchers found that the activity of a protein called tocopherol-associated protein (TAP), binds vitamin E and promotes its uptake in prostate cancer cells, thereby accelerating vitamin E’s anti-cancer effects in prostate cancer cells. In addition, they found that TAP levels were “significantly lower” in prostate cancer than in a normal prostate.

TAP increases vitamin E's capacity to control the rapid growth of the cancer cells and concluded that “TAP may represent a new prognostic marker for prostate cancer progression.”

Greg Arnold is a Chiropractic Physician practicing in Danville, CA. You can contact Dr. Arnold directly by emailing him at mailto:ChiroDocPSUalum@msn.com or visiting his website www.CompleteChiropracticHealthcare.com

Reference:

1 Miller ER 3rd. Meta-analysis: High-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 2005; 142: 37-46

2 Council for Responsible Nutrition’s rebuttal to Annals of Internal Medicine Medicine study on the safety of Vitamin E www.crnusa.org/vitaminEissafe.html

3 Ziaei, S., M. Zakeri, et al. (2005). "A randomised controlled trial of vitamin E in the treatment of primary dysmenorrhoea." Bjog 112(4): 466-9.

4 Morris, M. C., D. A. Evans, et al. (2005). "Relation of the tocopherol forms to incident Alzheimer disease and to cognitive change." Am J Clin Nutr 81(2): 508-14

5 Jiang, Q., J. Wong, et al. (2004). "(gamma)-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis." Proc Natl Acad Sci U S A 101(51): 17825-17830

6 Ascherio, A., M. G. Weisskopf, et al. (2004). "Vitamin E intake and risk of amyotrophic lateral sclerosis." Ann Neurol 57(1): 104-110.

7 Lee IM. Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer: The Women’s Health Study: A Randomized Controlled Trial. JAMA 2005: 294(1): 56-68.

8 Sen CK. Neuroprotective Properties of the Natural Vitamin E (alpha)-Tocotrienol. Stroke 2005; 30(10): e144-e152

9 Packer L. Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60(c-Src) kinase activation and death of HT4 neuronal cells. J Biol Chem. 2000;275:13049–13055

10 Sen CK. Vitamin E sensitive genes in the developing rat fetal brain: a high-density oligonucleotide microarray analysis. FEBS Letters. 2002;530:17–23.

11 Sen CK. Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration. J Biol Chem. 2003;278:43508–43515.

12 Stanford JL. Prostate Cancer Trends 1973-1995, SEER Program, NIH Pub, No. 99-4543. Bethesda, MD: National Cancer Institute, 1999.

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