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Herbal Remedies February 2008 Natural Health Newsletter Issue 279 Sponsored by www.HerbalRemedies.com Toll Free for orders 1-866-467-6444 Issue Editor - Heather Bowman

Herbs - Vitamins - Minerals - Magnetics - Candles - Aromatherapy - Holiday Gifts - Bath & Beauty - Essential Oils - Natural Pet Care - Condition & Ailment Guide - Women's Health - Men's Health - Weight Loss - Health Books Folic Acid Found to Benefit Mental Health - Click here for full story. Soy Cholesterol-Lowering Mechanism Identified - Click here for full story. Study Finds Migraines Increase Stroke Risk - Click here for full story. Beyond Joint Health, Pomegranate Extract May Help Newborn Brain Health - Click here for full story. Vitamin D May Play a Role in Prostate Health - Click here for full story. Herbal Remedies has 2 partner sites be sure to check them out as well: Magnetic Therapy Magnets , and Natural Hair Loss Remedies Be sure to check out our Overstocked clearance items! OVERSTOCKED Does you skin need a winter lift? Try adding the natural glow with Burt's Bees Products. We are your #1 Headquarters for your complete line of Burt’s Bees Products this wintery season!! • Herbal Remedies has four new vendors be sure to check them out: Herbal Remedies USA Products , Dr Bronner’s Castile Soaps , Tints of Nature/ Naked Earth Permanent Organic Hair Color Products, and Burt's Bees Men's Products Products Spotlight – Now you can color your hair permanently organic! Tints of Nature is the only available line of permanent hair colors to use natural, certified organic ingredients wherever feasible. The highly effective formula also has a naturally derived base. It is paraben free and contains no harsh ammonia, resorcinol or nonoxynol, thus helping to ensure damage free results. We use extra mild, low odor, pharmaceutical grade peroxide and the lowest possible percentage of PPD pigments (Paraphenylenediamines) - ranging from 1N (the darkest) at 2.0% to 10XL (the lightest) at 0.03% - giving an average of 0.6% across the line. You can darken your hair by several shades, lighten it by 1- 1 1/2 shades, simply match or even enhance your natural color, and gently but effectively cover all grey hair. You can choose the color and we take care of the condition - leaving your hair soft and silky with a deep and lasting shine. All Tints of Nature natural organic hair color boxed products use a unique earth-friendly packaging system. Tints of Nature products contain no animal ingredients, nor are they tested on animals. These products are easy to use, much easier than henna, try Tints of Nature today! Current Event News: HOW DO I LOVE THEE? LET ME SHOW YOU THE WAYS! Just because Valentine’s Day is over doesn’t mean you can’t show your partner how much you care now and throughout the year, thanks to some helpful aphrodisiacs we can help spice up your nights! We are your Headquarters for a complete line of Herbal Aphrodisiacs for month of love! Herbal Remedies New Years Specials- Just in Time to keep you on track with your New Year Goals! Be sure to check out all of our Coupon Savings and with these kind of prices you can afford to stock up! QUESTIONS AND ANSWERS Q: Subject: Hello Hi In Truman's Ginseng Power + 6 Tincture, 100% Organic - 2 fl. oz. how many servings per bottle? How much of each ginseng do you get per serving? Many thanks A: Dear Customer, Truman's Ginseng Power + 6 Tincture, 100% Organic - 2 fl. oz. servings are as follows: 1 drop = 26 mg, 38 drops = 1 gram, 1cc =37 40 drops, 2 ounces = 200 drops* = 1000 (500 mg) capsules 2 ounces = 80 squirts, 1 squirt = 25 drops. There are seven herbs in the Truman's Ginseng Power + 6 and the blend amount of each is proprietory. All my best, Thank you for your interest in Herbal Remedies.com and the opportunity to serve you. Heather * The statements regarding these products have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. The information on this Web site or in emails is designed for educational purposes only. It is not intended to be a substitute for informed medical advice or care. You should not use this information to diagnose or treat any health problems or illnesses without consulting your pediatrician or family doctor. Please consult a doctor with any questions or concerns you might have regarding you or your child's condition. Informational material and representations have been provided by the manufacturers of the listed products. Our Sponsors Enter coupon code "NL022708" when checking out to obtain discounts on your next purchase from http://www.HerbalRemedies.com. How would you like to save $10.49 or more off your next order? You CAN by using your 5% off coupon in conjunction with our $5.49 automatic shipping discount for orders over $75. The more you order the more you save!!! All previous sales and previous sale items excluded , only one coupon code per order

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Folic Acid Found to Benefit Mental Health By Greg Arnold, DC, CSCS, December 31, 2007, abstracted from “Plasma folate concentration and cognitive performance: Rotterdam Scan Study” in the September 2007 issue of the American Journal of Clinical Nutrition Folic acid is best known for helping reduce birth defects by 23% in the 1990’s through its fortification of the food supply.(1) It is found in highest amounts in leafy green vegetables, fruits, dried beans, peas and nuts(2). Folic acid’s benefits also extend to other areas of health, including digestive health (3), heart health (4) and breast cell health (5). A 2005 study(6) found that folic acid helps maintain mental health by slowing cognitive decline. Building on this finding, a new study(7) has found that folic acid can also maintain mental health and performance on tests of psychomotor speed. In the study, nearly 1,100 participants aged 60 to 90 years from the Rotterdam study(8) gave blood samples and underwent a number of neuropsychological tests. These included verbal fluency via a Stroop Test and Letter-Digit Substitution Task and memory via a 15-word verbal learning test and 3 immediate trials and a delayed recall of words. Finally, each patient underwent a brain MRI to examine each patients brains for what’s called “white matter lesions” which signify a decrease in brain blood vessel health(9). The researchers found no associations between folic acid and memory function (which is in contrast to the aforementioned 2005 study). However, significant differences between the highest (more than 17.3 nanomoles per Liter) and lowest (less than 8.1 nanomoles per Liter) blood levels of folic acid were seen with the Stroop test and the one-letter subtask of the Paper-and-Pencil Memory Scanning test. No significant association was observed for the Letter-Digit Substitution Task and the 15-word verbal learning test. The brain MRI tests also showed “a significant decrease” of severe white matter lesions in the highest intake folic acid group, signifying folic acid’s ability to help maintain blood vessel health in the brain. While observing that “a higher…concentration of folate was associated with better cognitive performance, in particular psychomotor speed” and “a significant inverse association between plasma folate and the presence of severe [brain lesions] was found”, the researchers concluded that “folate status is related to cognition through vascular mechanisms rather than through a primary neurodegenerative process.” Greg Arnold is a Chiropractic Physician practicing in Danville, CA. You can contact Dr. Arnold directly by emailing him at mailto:PitchingDoc@msn.com or visiting his web site at www.CompleteChiropracticHealthcare.com Reference: 1 “Spina Bifida and Anencephaly Before and After Folic Acid Mandate --- United States, 1995--1996 and 1999—2000” from MMWR Weekly 2004; 53(17): 362-365 2 “Folic Acid” posted on www.nlm.nih.gov/medlineplus/folicacid.html 3 “Inflammatory Bowel Disease” posted on the www.Emedicine.com website June 9, 2004 4 Wang X. Efficacy of folic acid supplementation in stroke prevention: a meta-analysis. The Lancet 2007; 369(9576):1876-1882 5 Ericson U. High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmö Diet and Cancer cohort Am. J. Clinical Nutrition, Aug 2007; 86: 434 – 443 6 “The First Ever Dementia Conference Opens In Washington, DC” posted on the Alzheimer’s Association Website 7 Ericson U. High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmö Diet and Cancer cohort Am. J. Clinical Nutrition, Aug 2007; 86: 434 – 443 8 de Groot JC, de Leeuw FE, Oudkerk M, et al. Cerebral white matter lesions and cognitive function: the Rotterdam Scan Study. Ann Neurol 2000;47:145–51 9 Vermeer SE, van Dijk EJ, Koudstaal PJ, et al. Homocysteine, silent brain infarcts, and white matter lesions: The Rotterdam Scan Study. Ann Neurol 2002;51:285–9

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Soy Cholesterol-Lowering Mechanism Identified By Greg Arnold, DC, CSCS, January 18, 2008, abstracted from “Cholesterol Lowering Mechanism of Soybean Protein Hydrolysate” in the December 26, 2007 issue of the Journal of Agriculture and Food Chemistry In 2005, the American Heart Association estimated that nearly 81 million Americans had one or more forms of cardiovascular disease (CVD), including high blood pressure (73 million), heart disease (16 million), stroke (5.8 million) and heart failure (5.3 million). In 2004 alone, CVD killed nearly 900,000 Americans and accounted for one of every 2.8 deaths in the U.S.(1). Elevated cholesterol levels play a role in the onset of CVD, with nearly 107 million Americans having cholesterol levels of 200 mg/dL or higher and 37% of those having levels of 240 mg/dL or more(2). Now a new study(3) has found just how soy, found in previous research to significantly lower total cholesterol , LDL cholesterol and triglycerides without affecting HDL cholesterol(4), helps maintain healthy cholesterol levels. In the study, researchers sought to find if soy protein maintains healthy cholesterol levels through any of the following mechanisms: (1) inhibition of bile acid and/or cholesterol absorption, (2) inhibition of cholesterol synthesis, and (3) increased formation of the LDL cholesterol receptor (LDL-R). They compared soy protein isolate to soy protein isoflavones and their effects on these three possible mechanisms by exposing them to liver cells. The researchers found that soy protein isolates given in amounts of 1000 micrograms per milliliter of solution were able to increase LDL receptor formation activity by 15%. This increased LDL-R formation may increase LDL cholesterol up-take in liver and eventually reduce blood LDL cholesterol level(5). The other two mechanisms were not affected by either the isoflavones or soy protein and the soy protein was the only soy sample to improve LDL-R formation. Unfortunately, the researcher didn’t cite the specific soy protein amounts in grams that produced the LDL-R benefits. Nevertheless, the researchers concluded that “soy peptides can effectively stimulate LDL-R transcription in the human liver cell line and reduce blood cholesterol level.” Greg Arnold is a Chiropractic Physician practicing in Danville, CA. You can contact Dr. Arnold directly by emailing him at mailto:PitchingDoc@msn.com or visiting his web site at www.CompleteChiropracticHealthcare.com Reference: 1 “Cardiovascular Disease Statistics” posted on www.americanheart.org/presenter.jhtml?identifier=4478 2 “Cholesterol Statistics” posted on www.americanheart.org/presenter.jhtml?identifier=4506 3 Cho SJ. Cholesterol Lowering Mechanism of Soybean Protein Hydrolysate. Jou Agr Food Chem 2007; 55(26): 10599 – 10604 4 Anderson, J. W.; Johnstone, B. M.; Cook-Newell, M. E. Meta-analysis of the effects of soy protein intake on serum lipids. N. Engl. J. Med. 1995, 333, 276–282 5 Pal, S.; Thomson, A. M.; Bottema, C. D. K.; Roach, P. D. Polyunsaturated fatty acids downregulate the low density lipoprotein receptor of human HepG2 cells. J. Nutr. Biochem. 2002, 13, 55–64

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Study Finds Migraines Increase Stroke Risk By Greg Arnold, DC, CSCS, January 11, 2008, abstracted from “Migraine and the Risk of Stroke, TIA, or Death in the UK” in the March 2008 issue of Headache Migraine headaches affect more than 28 million Americans, with one in every four households having a migraine sufferer(1). The cost to society imposed by migraines is also significant: migraine sufferers lose an average of four to six work days each year, totaling 64 to 150 million work days each year and costing almost $17 billion(2). Migraines are also present in children, affecting as many as 13 percent of them(3). Now a new study(4) has found that having a migraine significantly increases your risk for stroke , building on a 2006 study(5) showing that migraines increase heart attack risk in men. In the study, researcher accessed a British General Practice Research Database (GPRD) containing computerized medical records of some 3 million people(6). The database includes information on patient demographics (age, gender), diagnoses, drug prescriptions, referrals, and hospital admissions as well as some lifestyle information (e.g. smoking status) and has been validated repeatedly and proven to be of high quality(7). The researchers proceeded to compare 51,688 patients with migraines to 51,688 matched controls, nearly 72% of which were female. The researchers found that not only did having a migraine more than double the risk for stroke, it also more than doubled the risk of having a Transient Iscehmic Attach (TIA), which is a min-stroke that lasts only a few minutes when blood flow in the brain is temporarily interrupted(8). The researchers then found that triptans, a common new migraine headache medication that increases both the cost of treating migraines(9) but also the quality of life of those suffering from migraines(10, 11), did not increase stroke risk. For the researchers, this study “provides further evidence for migraine as a risk factor for stroke and TIA with an approximately 2-fold increased risk for these outcomes.” For patients who wish to avoid taking migraine medications, research has found 150 mg of Coenzyme Q10 per day(12), 150 mg butterbur extract (13), and 500 mg magnesium per day(14) to help with mental health regarding migraines. Greg Arnold is a Chiropractic Physician practicing in Danville, CA. You can contact Dr. Arnold directly by emailing him at mailto:PitchingDoc@msn.com or visiting his web site at www.CompleteChiropracticHealthcare.com Reference: 1 National Headache Foundation. NHF headache facts. www.headaches.org/consumer/educationgeneralindex.html 2 Hu, X.H., et al., Burden of migraine in the United States: disability and economic costs. Arch Intern Med, 1999. 159(8): p. 813-8 3 Abu-Arefeh I. Prevalence of headache and migraine in school children. British Medical Journal 1994; 309: 765-769 4 Becker MSc. Migraine and the Risk of Stroke, TIA, or Death in the UK (CME). Headache: The Journal of Head and Face Pain 2007;47(10):1374–1384 doi:10.1111/j.1526-4610.2007.00937.x 5 American Heart Association Scientific Sessions; Chicago, Illinois, USA: 12–15 November 2006 6 Jick H. A database worth saving. Lancet. 1997;350:1045-1046 7 Jick H, Jick SS, Derby LE. Validation of information recorded on general practitioner based computerised data resource in the United Kingdom. BMJ. 1991;302:766-768 8 “NINDS Transient Ischemic Attack” posted on www.ninds.nih.gov/disorders/tia/tia.htm 9 Goldberg LD. The cost of migraine and its treatment. Am J Manag Care. 2005;11(2 Suppl.):S62-S67 10 Lainez MJ, Lopez A, Pascual AM. Effects on productivity and quality of life of rizatriptan for acute migraine: A workplace study. Headache. 2005;45:883-890 11 Dahlof C, Bouchard J, Cortelli P, et al. A multinational investigation of the impact of subcutaneous sumatriptan. II: Health-related quality of life. Pharmacoeconomics. 1997;11(Suppl.1):24-34 12 Rozen, T. D., M. L. Oshinsky, et al. (2002). "Open label trial of coenzyme Q10 as a migraine preventive." Cephalalgia 22(2): 137-41 13 Pothmann, R. Migraine Prevention in Children and Adolescents: Results of an Open Study With a Special Butterbur Root Extract. Headache 2005; 45(3): 196-203 14 Wang, F., et al., Oral magnesium oxide prophylaxis of frequent migrainous headache in children: a randomized, double-blind, placebo-controlled trial. Headache 2003; 43(6): 601-10

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Beyond Joint Health, Pomegranate Extract May Help Newborn Brain Health By Greg Arnold, DC, CSCS, November 18, 2007, abstracted from “Pomegranate Polyphenols and Resveratrol Protect the Neonatal Brain against Hypoxic-Ischemic Injury” in the August 2007 issue of Developmental Neuroscience The pomegranate originated in lands ranging from Iran to the Himalayas in northern India and was cultivated and naturalized over the whole Mediterranean region since ancient times. The pomegranate tree was introduced into California by Spanish settlers in 1769 and is currently grown mainly in the drier parts of California and Arizona(1). Research on pomegranates over the past few years has started to highlight their potential health benefits. A 2005 study(2) found that pomegranate extract stopped the activity of an inflammatory protein called Interleukin-1b which is responsible for the cartilage breakdown that is the hallmark of osteoarthritis (3). This condition limits everyday activities for 16 million Americans, results in 750,000 hospitalizations and costs our healthcare system over $51 billion each year(4). Since 2005, more research has surfaced showing that pomegranate extract benefits prostate health (5) and cholesterol health(6). Now a new study in mice(7) pomegranates may provide hope in helping maintain newborn brain health. In the study, researchers had pregnant mice drink water with pomegranate extract that was equivalent to an intake of 4.8 mg of polyphenols per day for each mouse in the pomegranate group during the entire pregnancy. When the babies were born, the researchers simulated an oxygen-deprived condition called hypoxia in the baby mice and then measured brain levels of an enzyme called caspsae-3. This enzyme has been found to be a reliable measure of the extent of nerve cell death in the newborn brain due to hypoxia(7). In a separate group of baby mice, researchers administered doses of the antioxidant resveratrol in levels of either high-dose (20 mg per kg of bodyweight), medium-dose (200 micrograms per kg of bodyweight), or low dose (2 micrograms per kg of bodyweight) 10 minutes before the hypoxic period began and also measured caspase-3 activity. The researchers found that the baby mice given the pomegranate extract “had significantly less caspase-3 activity in the [brain]” (~40% less) than did mice in the placebo group and stated that “the polyphenols in the pomegranate juice were responsible for the [nerve protection].” They found similar results among the high and medium doses of resveratrol on caspase-13 activity (~50% decreased caspase-3 levels compared to placebo). For the researchers, “these and other recent findings suggest that polyphenols should be further investigated as a potential treatment to decrease brain injury due to neonatal [exposure to hypoxia].” Greg Arnold is a Chiropractic Physician practicing in Danville, CA. You can contact Dr. Arnold directly by emailing him at mailto:PitchingDoc@msn.com or visiting his web site at www.CompleteChiropracticHealthcare.com Reference: 1 “Pomegranate Fruit Facts” posted on www.crfg.org/pubs/ff/pomegranate.html 2 Ahmed S. Punica granatum L. Extract Inhibits IL-1(beta)-Induced Expression of Matrix Metalloproteinases by Inhibiting the Activation of MAP Kinases and NF-(kappa) B in Human Chondrocytes In Vitro. J Nutr. 2005 Sep;135(9):2096-102,p> 3 Chevalier X. Safety study of intraarticular injection of interleukin 1 receptor antagonist in patients with painful knee osteoarthritis: a multicenter study. J Rheumatol. 2005 Jul; 32(7): 1317-23 4 “Targeting Arthritis: Reducing Disability for 43 Million Americans” posted on the CDC Website www.cdc.gov/nccdphp/aag/aag_arthritis.htm 5 Adhami VM. Anti-oxidants from green tea and pomegranate for chemoprevention of prostate cancer. Mol Biotechnol. 2007 Sep;37(1):52-7. 6 Sezer ED. Pomegranate wine has greater protection capacity than red wine on low-density lipoprotein oxidation. J Med Food. 2007 Jun;10(2):371-4,p> 7 West T. Pomegranate Polyphenols and Resveratrol Protect the Neonatal Brain against Hypoxic-Ischemic Injury. Developmental Neuroscience 2007;29:363-372 8 Han BH, D’Costa A, Back SA, Parsadanian M, Patel S, Shah AR, Gidday JM, Srinivasan A, Deshmukh M, Holtzman DM (2000): BDNF blocks caspase-3 activation in neonatal hypoxia- ischemia. Neurobiol Dis 7: 38–53.

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Vitamin D May Play a Role in Prostate Health By Greg Arnold, DC, CSCS, December 31, 2007, abstracted from “Comprehensive Association Analysis of the Vitamin D Pathway Genes, VDR, CYP27B1, and CYP24A1, in Prostate Cancer” in the October 2007 issue of Cancer Epidemiology and Prevention After lung cancer , prostate cancer is the second leading cause of cancer deaths in American men(1). Fortunately, a number of foods and supplements have been found to help maintain prostate health, including lycopene and vitamin E (2), soy protein (3), spinach(4), broccoli (5), red wine (6) and green tea (7). Even avoiding processed foods(8) and foods high in starch(9) may help prostate health. Now a new study(10), building on previous research in 2000(11) and 2004(12, 13, 14) that found vitamin D to help with prostate health, provides more evidence that prostate health may benefit from the action of the vitamin D receptor (VDR). In the study, researchers analyzed the VDR and two genes involved in vitamin D metabolism - CYP27B1 and CYP24A1, and how these changes can affect the risk of prostate cancer. When researchers analyzed blood samples from 630 patients with prostate cancer and 565 patients without prostate cancer, they found that when these two genes were altered, the patients were 2.5 and 2 times more likely to get prostate cancer, respectively. For the researchers, “Our findings suggest that changes in the VDR gene may be associated with prostate cancer risk and, therefore, that the vitamin D pathway might have an etiologic role in the development of prostate cancer.” Greg Arnold is a Chiropractic Physician practicing in Danville, CA. You can contact Dr. Arnold directly by emailing him at mailto:PitchingDoc@msn.com or visiting his web site at www.CompleteChiropracticHealthcare.com Reference: 1 Stanford JL. Prostate Cancer Trends 1973-1995, SEER Program, NIH Pub, No. 99-4543. Bethesda, MD: National Cancer Institute, 1999 2 Limpens J. Combined Lycopene and Vitamin E Treatment Suppresses the Growth of PC-346C Human Prostate Cancer Cells in Nude Mice J. Nutr. 2006 136: 1287-1293 3 Hedelin M. Dietary Phytoestrogen, Serum Enterolactone and Risk of Prostate Cancer: The Cancer Prostate Sweden Study. Cancer Causes and Control 2006; 17(2): 169-180 4 Asai, A., M. Terasaki, and A. Nagao, An epoxide-furanoid rearrangement of spinach neoxanthin occurs in the gastrointestinal tract of mice and in vitro: formation and cytostatic activity of neochrome stereoisomers. J Nutr, 2004. 134(9): p. 2237-43 5 Wang, L., et al., Targeting cell cycle machinery as a molecular mechanism of sulforaphane in prostate cancer prevention. Int J Oncol, 2004. 24(1): p. 187-92 6 Schoonen, W. M., C. A. Salinas, et al. (2005). "Alcohol consumption and risk of prostate cancer in middle-aged men." Int J Cancer 113(1): 133-40 7 Chung, L. Y., T. C. Cheung, et al. (2001). "Induction of apoptosis by green tea catechins in human prostate cancer DU145 cells." Life Sci 68(10): 1207-14 8 Walker M, Aronson KJ, King W, et al. Dietary patterns and risk of prostate cancer in Ontario, Canada. International Journal of Cancer, Sep. 10, 2005;116:592-598 9 Bidoli, E., R. Talamini, et al. (2005). "Macronutrients, fatty acids, cholesterol and prostate cancer risk." Ann Oncol 16(1): 152-7 10 Holick CN. Comprehensive Association Analysis of the Vitamin D Pathway Genes, VDR, CYP27B1, and CYP24A1, in Prostate Cancer. Cancer Epidemiol Biomarkers Prev 2007 16: 1990-1999 doi: 10.1158/1055-9965.EPI-07-0487 11 Ahonen MH, Tenkanen L, Teppo L, Hakama M, Tuohimaa P. Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels (Finland). Cancer Causes Control 2000;11:847–52 12 Jacobs ET, Giuliano AR, Martinez ME, Hollis BW, Reid ME, Marshall JR. Plasma levels of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D and the risk of prostate cancer. J Steroid Biochem Mol Biol 2004;89–90:533–7. 13 Platz EA, Leitzmann MF, Hollis BW, Willett WC, Giovannucci E. Plasma 1,25-dihydroxy- and 25-hydroxyvitamin D and subsequent risk of prostate cancer. Cancer Causes Control 2004;15:255–65 14 Tuohimaa P, Tenkanen L, Ahonen M, et al. Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries. Int J Cancer 2004;108:104–8 Do you have a question for us? If so please send in your questions to newsletter@herbalremedies.com We will answer all email ASAP!

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For assistance or to purchase products by phone call toll free in the USA 1-866-467- 6444 or World Wide 1-307-577-6444 or e-mail your questions to newsletter@herbalremedies.com. We will answer e-mails in the newsletter as space allows. Our Sponsors HerbalRemedies.com Get the finest all natural health products, get the best service, and low cost worldwide delivery. Enter coupon code "NL022708" when checking out to obtain discounts on your next purchase from www.HerbalRemedies.com How would you like to save $10.49 or more off your next order? You CAN by using your 5% off coupon in conjunction with our $5.49 automatic shipping discount for orders over $75. The more you order the more you save!!! Only one coupon per order!