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DescriptionExtracts of Hypericum perforatum L. (St John's wort) are now successfully competing for status as a standard antidepressant therapy. Because of this, great effort has been devoted to identifying the active antidepressant compounds in the extract. From a phytochemical point of view, St John's wort is one of the best-investigated medicinal plants. A series of bioactive compounds has been detected in the crude material, namely flavonol derivatives, biflavones, proanthocyanidines, xanthones, phloroglucinols and naphthodianthrones. Although St John's wort has been subjected to extensive scientific studies in the last decade, there are still many open questions about its pharmacology and mechanism of action. Initial biochemical studies reported that St John's wort is only a weak inhibitor of monoamine oxidase-A and -B activity but that it inhibits the synaptosomal uptake of serotonin, dopamine and noradrenaline (norepinephrine) with approximately equal affinity. However, other in vitro binding assays carried out using St John's wort extract demonstrated significant affinity for adenosine, GABA(A), GABA(B) and glutamate receptors. In vivo St John's wort extract leads to a downregulation of beta-adrenergic receptors and an upregulation of serotonin 5-HT(2) receptors in the rat frontal cortex and causes changes in neurotransmitter concentrations in brain areas that are implicated in depression. In studies using the rat forced swimming test, an animal model of depression, St John's wort extracts induced a significant reduction of immobility. In other experimental models of depression, including acute and chronic forms of escape deficit induced by stressors, St John's wort extract was shown to protect rats from the consequences of unavoidable stress. Recent neuroendocrine studies suggest that St John's wort is involved in the regulation of genes that control hypothalamic-pituitary-adrenal axis function. With regard to the antidepressant effects of St John's wort extract, many of the pharmacological activities appear to be attributable to the naphthodianthrone hypericin, the phloroglucinol derivative hyperforin and several flavonoids. This review integrates new findings of possible mechanisms that may underlie the antidepressant action of St John's wort and its active constituents with a large body of existing literature.Ingredients
St. John's Wort extract (upper parts of flower and leaves), sucrose, lactose, powdered cellulose, talc, hydroxypropyl methylcellulose, silica, acacia, titanium dioxide (mineral based whitening pigment), magnesium stearate, vegetable oil, polyvinylpyrrolidone, white beeswax,canauba wax.
Serving Size: 1 Tablet
|Amount Per Serving||% DV|
|St. John's Wort Extract (flowers & leaves) (Hypericum perforatum L.)||300 mg|
Free of: preservative, yeast, and gluten.
Kira St. John's Wort is non-habit forming, does not have a sedative effect and has not interactions with alcohol. No interaction with caffeine has been observed.
|St. Johns Wort, 350 mg- 180 capsSt. John's Wort Supplement can be helpful in support of depression, menopause, cramps, and insomnia. Nature's Way St. John's Wort extract standardized to .3% Hypericin, then synergistically blended with the whole St. John's Wort herb in the perfect balance to ensure consistent hypericin content in each capsule.|
|St Johns Wort Herb Tea, 20 bagSt. John's Wort Herb Tea is made of wild St. John's Wort and Siberian Ginseng. These Herbs tonify the nervous system, ease anxiety and depression, and support the immune system.|
|Perika St. Johns Wort, 60 tabNature's Way St. John's Wort is scientifically advanced to maintain a healthy emotional outlook.|
|St. Johns Wort Stndrdzd, Extract, 300 mg- 90 capsSt. John's Wort Extract has been proven in many European clinical studies to be a natural antidepressant and is widely used for this reason.|
|St. Johns Wort ( Hypericum perforatum ) Powder - 4 oz. BulkSt. John's Wort is mainly used for the treatment of mild to moderate depression.|
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