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Herbal Remedies Natural Health Newsletter, November 2007, Issue 277

Herbal Remedies November 2007 Natural Health Newsletter Issue 277 Sponsored by www.HerbalRemedies.com Toll Free for orders 1-866-467-6444 Issue Editor - Heather Bowman

Herbs - Vitamins - Minerals - Magnetics - Candles - Aromatherapy - Holiday Gifts - Bath & Beauty - Essential Oils - Natural Pet Care - Condition & Ailment Guide - Women's Health - Men's Health - Weight Loss - Health Books Cruciferous Vegetables Continue to Exhibit Heart Health Benefits - Click here for full story. Flaxseed Found Beneficial for Hot Flashes - Click here for full story. Vitamin D Deficiency Common in Chronic Pain - Click here for full story. Supplements are Related to Better Dietary Habits in Over-50 Population - Click here for full story. Soy Component Found Effective for Joint Health - Click here for full story. Herbal Remedies has 2 partner sites be sure to check them out as well: Magnetic Therapy Magnets , and Natural Hair Loss Remedies Be sure to check out our Overstocked clearance items! OVERSTOCKED Does you skin need a winter lift? Try adding the natural glow with Burt's Bees Products. We are your #1 Headquarters for your complete line of Burt’s Bees Products this holiday season!! Herbal Remedies has five new vendors be sure to check them out: Thunder Ridge Emu Oil Products , Humm Foods , Earth Friendly Products, Alba Botanica and Herbal Remedies USA Tinctures Products Spotlight – Are you prepared NATURALLY for the COLD & FLU SEASON? Feel better Faster! Clinically tested UMCKA shortens the duration and reduces the severity of throat, sinus and bronchial irritations. It provides effective relief of upper respiratory tract irritations. Unlike other remedies that simply mask symptoms, UMCKA helps you recover faster! Now in new chewable tablets for easy dosing. Umcka Cold + Flu Berry Chewable Tablets combine two clinically tested natural ingredients into one complete, multi-action cold and flu formula. Current Event News: Gift giving made easy. Just think Gift Baskets . How do you shop for the hard-to-buy-for-ones on your list - like your child’s teacher, daycare provider, co-workers? You could can get them a gift certificate – but maybe you want to give something a little bit more personal? Consider giving Gift Baskets . The holiday season is the perfect time to say “thank you” to those who have been there for you throughout the year - to let them know you're pleased with what they do for you. A monetary gift or gifts that you have selected personally are both appropriate for anyone on your shopping list and what better way to say thank you than saying it naturally! Manager’s Holiday Special- Just in Time for the Holidays! Be sure to check out all of our Holiday Coupon Savings and with these kind of prices you could build your own gift baskets! QUESTIONS AND ANSWERS Q: Subject: Hello Hi What percent of your juice is acai berry? Many thanks A: Dear Customer, Here is our Acai product page and it states 6500mg(6.5g) in a 2 tablespoon serving: All my best, Thank you for your interest in Herbal Remedies.com and the opportunity to serve you. Heather * The statements regarding these products have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. The information on this Web site or in emails is designed for educational purposes only. It is not intended to be a substitute for informed medical advice or care. You should not use this information to diagnose or treat any health problems or illnesses without consulting your pediatrician or family doctor. Please consult a doctor with any questions or concerns you might have regarding you or your child's condition. Informational material and representations have been provided by the manufacturers of the listed products. Our Sponsors Enter coupon code "NL112807" when checking out to obtain discounts on your next purchase from http://www.HerbalRemedies.com. How would you like to save $10.49 or more off your next order? You CAN by using your 5% off coupon in conjunction with our $5.49 automatic shipping discount for orders over $75. The more you order the more you save!!! All previous sales and previous sale items excluded , only one coupon code per order

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Cruciferous Vegetables Continue to Exhibit Heart Health Benefits By Greg Arnold, DC, CSCS, October 3, 2007, abstracted from “Cruciferous Indole-3-Carbinol Inhibits Apolipoprotein B Secretion in HepG2 Cells” in the October 2007 issue of the Journal of Nutrition As evidence continues to mount that increased consumption of fruits and vegetables helps maintain heart health ,(1) more research has started to find some fruits and vegetables are more valuable than others. Specifically, cruciferous vegetables , which include broccoli , cabbage, cauliflower , Brussels sprouts , turnip, and radish,(2) have been found to offer the most heart health benefits(3) and seem to owe this health-promoting property to antioxidants called indoles.(4) While an antioxidant in broccoli called sulfurophane has been shown to help prostate health,(5) another antioxidant called Indole-3-Carbinol (I3C) has been found beneficial for overall cell health,(6) infant health(7) and detoxification .(8) Now a new study(9) has found that I3C maintains heart health by helping control the accumulation of a protein called apoB-Lp which is the major component of the “bad” cholesterol LDL and VLDL. In the study, researchers exposed liver cells (called HepG2) to I3C and measured apoB-Lp levels as well as overall triglyceride and cholesterol levels. At a dosage of 0.74 milligrams, I3C’s inhibition of apoB-Lp caused a decrease in the production of triglycerides and cholesterol by as much as 50% compared to controls. In addition to stating that this study is “the first report to our knowledge to indicate that plant indoles possess the ability to decrease the number of apoB-Lp secreted,” the researchers concluded that “Together, plant indoles resulted in beneficial effects on lipid metabolism that could contribute to their potential cardioprotective effect.” Greg Arnold is a Chiropractic Physician practicing in Danville, CA. You can contact Dr. Arnold directly by emailing him at mailto: PitchingDoc@msn.com or visiting his web site at www.CompleteChiropracticHealthcare.com Reference: 1 Bazzano LA, Serdula MK, Liu S. Dietary intake of fruits and vegetables and risk of cardiovascular disease. Curr Atheroscler Rep. 2003;5:492–9. 2 Keck AS, Finley JW. Cruciferous vegetables: cancer protective mechanisms of glucosinolate hydrolysis products and selenium. Integr Cancer Ther. 2004;3:5–12 3 Feldman EB. Fruits and vegetables and the risk of stroke. Nutr Rev. 2001;59:24–7. 4 Pedras MS, Nycholat CM, Montaut S, Xu Y, Khan AQ. Chemical defenses of crucifers: elicitation and metabolism of phytoalexins and indole-3-acetonitrile in brown mustard and turnip. Phytochemistry 2002;59:611–25. 5 Wang, L., et al., Targeting cell cycle machinery as a molecular mechanism of sulforaphane in prostate cancer prevention. Int J Oncol, 2004. 24(1): p. 187-92 6 Arora A. Modulation of vinca-alkaloid-induced P-glycoprotein expression by indole 3-carbinol. Cancer Letters 2003; 189: 167-173 7 Williams DE. Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene. Carcinogenesis Advance Access published on May 16, 2006 Carcinogenesis 2006 27: 2116-2123 8 Finley JW. The antioxidant responsive element (ARE) may explain the protective effects of cruciferous vegetables on cancer. Nutr Rev. 2003 Jul;61(7):250-4. Review 9 Maiyoh GK. Cruciferous Indole-3-Carbinol Inhibits Apolipoprotein B Secretion in HepG2 Cells. J. Nutr. 137: 2185–2189, 2007.

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Flaxseed Found Beneficial for Hot Flashes By Greg Arnold, DC, CSCS, August 29, 2007, abstracted from “Pilot Evaluation of Flaxseed for the Management of Hot Flashes“ printed online in the Journal of the Society for Integrative Oncology Hot flashes are one of the most common physical changes experienced by women in menopause (in addition to changes in cardiovascular health , bone mineral density, and cognitive function).(1) They are often felt and seen as a redness of the upper face, neck, and chest that results from increased temperature blood flow in the skin.(2) They can last from 6 months to 2 years,(3) can be “a major disruption in the quality of life”(4) and may even increase blood pressure.(5) Because of the health risks of hormone replacement therapy,(6) interest in natural treatments is ever more prevalent. While soy has consistently been found to be helpful for hot flashes,(7) a new study(8) has found that flaxseed , found in previous research to help with blood sugar health,(9) cell health,(10) and lung health ,(11) may also help with symptoms of hot flashes. In the study, 29 postmenopausal women were given either 40 grams of flaxseed or placebo for six weeks. They then completed questionnaires regarding their hot flash severity. They found that by the end of six weeks not only did hot flashes decrease by 50% but the overall questionnaire scores decreased by 57% due to additional improvements in mood, joint or muscle pain, chills and sweating. For the researchers, “Not only does flaxseed seem to alleviate hot flashes, but it appears to have overall health and psychological benefits as well." Greg Arnold is a Chiropractic Physician practicing in Danville, CA. You can contact Dr. Arnold directly by emailing him at mailto:PitchingDoc@msn.com or visiting his web site at www.CompleteChiropracticHealthcare.com Reference: 1 Philp HA. Hot flashes-a review of the literature on alternative and complementary treatment approaches. Altern Med Rev 2003; 8:284-302 2 Freedman RR. Pathophysiology and treatment of menopausal hot flashes. Semin Reprod Med 2005; 23:117-125 3 Kronenberg F. Hot flashes: epidemiology and physiology. Ann N Y Acad Sci 1990; 592:52-86, discussion 123-33 4 Sikon A, Thacker HL. Treatment options for menopausal hot flashes. Cleve Clin J Med 2004;71:578-582 5 Gerber, Linda M. Hot flashes are associated with increased ambulatory systolic blood pressure. Menopause 2007; 14: 308-15 6 Bath PMW. Association between hormone replacement therapy and subsequent stroke: a meta-analysis. BMJ online publication published January 7, 2005 7 Howes, L.G., J.B. Howes, and D.C. Knight, Isoflavone therapy for menopausal flushes: a systematic review and meta-analysis. Maturitas, 2006. 55(3): p. 203-11 8 Pruthi S. Pilot Evaluation of Flaxseed for the Management of Hot Flashe. Jou Soc Int Oncol 2007. Volume 5, Number 3, doi: 10.2310/7200.2007.007 9 Rhee Y. Pilot Study: Flaxseed Supplementation Was Effective in Lowering Serum Glucose and Triacylglycerol in Glucose Intolerant People. Jou Am Neut Assoc 2006; 9(1): 28-34 10 Thompson LU. Dietary flaxseed alters tumor biological markers in postmenopausal breast cancer. Clin Cancer Res. 2005 May 15;11(10):3828-35 11 Kinniry P. Dietary Flaxseed Supplementation Ameliorates Inflammation and Oxidative Tissue Damage in Experimental Models of Acute Lung Injury in Mice. J. Nutr. 2006 136: 1545-1551

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Vitamin D Deficiency Common in Chronic Pain By Greg Arnold, DC, CSCS, October 16, 2007, abstracted from “Prevalence and Clinical Correlates of Vitamin D Inadequancy among Patients with Chronic Pain” presented at the 2007 annual meeting of the American Society of Anesthesiologists Chronic pain permeates all areas of our healthcare system. According to Healthy People 2010, we spend $1.9 trillion on healthcare each year and “much of this spending is for care that controls or reduces the impact of chronic diseases and conditions affecting an aging population.” In 2004, 32% of those 75 years of age and over reported fair or poor health (due to chronic pain), compared with 22% of people age 65–74 and 6% of young adults age 25–44 years(1). Chronic pain is present in all areas of chronic disease, from arthritis to cardiovascular disease to diabetes . Now a new study(2) has found that chronic pain may have an underlying commonality and that is a deficiency in vitamin D . The health benefits of this antioxidant are numerous, including helping with immune system health (3), pregnancy health(4) and heart health(5) while helping decrease falls in the elderly(6) and helping increase physical activity in the elderly(7). In fact, Vitamin D has become such an important vitamin that it may be necessary to start vitamin D supplementation in children(8). As an antioxidant whose benefits in research have ranged from 400 IU(9) to 700 IU(10) per day, new research has started to recommend 2000 IU per day “for all individuals 12 years and older” and 1000 IU per day for children age 6 months to 11 years(11). No adverse effects of vitamin D have been observed with dosages up to 10,000 IU per day(12, 13). In the study, researchers drew blood samples from patients admitted to a local hospital from February 2006 through December 2006 who were seeking treatment for chronic pain. Classifying vitamin D deficiency as having a vitamin blood level below 20 nanograms per milliliter, they found that more than 1 in 4 of these chronic pain patients had a vitamin D deficiency. And those with vitamin D deficiency who were taking pain medications used their medications 62% more than those without a deficiency. For the researchers, “vitamin D [deficiency] may represent an under recognized source of [pain] and impaired neuromuscular functioning among patients with chronic pain.” Greg Arnold is a Chiropractic Physician practicing in Danville, CA. You can contact Dr. Arnold directly by emailing him at mailto: PitchingDoc@msn.com or visiting his web site at www.CompleteChiropracticHealthcare.com Reference: 1 Healthy People 2010 www.healthypeople.gov/ 2 Hooten WM. Prevalence and Clinical Correlates of Vitamin D Inadequancy among Patients with Chronic Pain. Abstracft A1380. Presented October 15, 2007 www.asaabstracts.com/strands/asaabstracts/abstract.htm;jsessionid=322B71A1205E5A48DE86C59DD815D36A?year=2007&index=3&absnum=1501 3 Martineau AR. A Single Dose of Vitamin D Enhances Immunity to Mycobacteria. Am. J. Respir. Crit. Care Med. 176: 208-213. First published online as doi:10.1164/rccm.200701-007OC 4 Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study. The Lancet 2006; 367:36-43 5 Poole KE. Reduced vitamin D in acute stroke. Stroke. 2006 Jan;37(1):243-5 6 Flicker, L. (2005). "Should older people in residential care receive vitamin d to prevent falls? Results of a randomized trial." J Am Geriatr Soc 53(11): 1881-8 7 Bunout D. Effects of vitamin D supplementation and exercise training on physical performance in Chilean vitamin D deficient elderly subject. Exp Gerontol 2007; 41(8): 746-752 8 Zipits CS. Vitamin D deficiency: primary or tertiary prevention? Arch Dis Child 2006;000:1–5 9 Pratt T. Bone mass and density response to a 12-month trial of calcium and vitamin D supplement in preadolescent girls. J Musculoskelet Neuronal Interact. 2003 Mar;3(1):63-70 10 Harris SS. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med. 1997 Sep 4;337(10):670-6 11 Hathcock JN, Shao A, Vieth R, Heaney R. Risk assessment for vitamin D. Am J Clin Nutr. 2007;85: 6–18 12 Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academies Press; 1997. Available at: www.nap.edu/books/0309063507/html 13 Vieth R. Why the optimal requirement for Vitamin D3 is probably much higher than what is officially recommended for adults. J Steroid Biochem Mol Biol. 2004;89-90:575–579

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Supplements are Related to Better Dietary Habits in Over-50 Population By Greg Arnold, DC, CSCS, September 25, 2007, abstracted from “Older Adults Who Use Vitamin/Mineral Supplements Differ from Nonusers in Nutrient Intake Adequacy and Dietary Attitudes“ in the August 2007 issue of the Journal of the American Dietetic Association. As millions of baby boomers age, one in five Americans will be 65 and older by 2030. The size of the older population is projected to double by 2030, growing to 70 million.(1) As the population ages, their dietary habits have been found to get progressively worse(2, 3) to the point that it puts them at risk for nutrition-related problems and chronic disease.(4, 5) And with chronic disease already costing our healthcare system 1.4 trillion dollars each year,(6) the need to bridge the gap in the nutrition requirements of the elderly is a priority. Fortunately, increasing numbers of the over-50 population are taking nutritional supplements (7, 8) that have the potential to bridge these nutritional gaps.(9) While compliance can be an issue,(10) supplements may be the only way to help this age group satisfy their nutrition requirements. Now a new study(11) has found a relationship between taking supplements and eating habits. Older supplement users not only have higher overall vitamin intakes, but they followed healthier diets to help produce those higher levels. In the study, researchers analyzed data from the US Department of Agriculture’s 1994-96 CSFII and Diet and Health Knowledge Survey,(12) which involved telephone interviews with nearly 4,000 people ages 51 and over. While they found that 37% of men and 47% of women consumed at least one type of supplement every day, 74% of male supplement users and 70% of female supplement users took multivitamins. Vitamin C and vitamin E were the most common single-vitamin supplements taken (19% of men and 34% of women). Compared to those not taking supplements, food intakes of vitamins A , C , B-6 and magnesium were “significantly higher” in the supplement group for users vs. nonusers in both age groups of men. More than 50% of both supplement users and nonusers, however, had inadequate intakes of folate and vitamin E . The news on folic acid comes as a shock, since a big campaign was undertaken in the 1980’s to fortify foods with folic acid such as breads and cereals.(13) The deficiencies are believed to be due to problems with nutrient absorption as we age.(14) For the researchers, “Supplements had a positive influence on nutrient adequacy for men and women aged 51 years and older.” While they cite that “dietary modifications to improve intake are paramount,” they conclude that “the use of supplements by older adults appears beneficial to attain nutrient adequacy.” Greg Arnold is a Chiropractic Physician practicing in Danville, CA. You can contact Dr. Arnold directly by emailing him at mailto:PitchingDoc@msn.com or visiting his web site at www.CompleteChiropracticHealthcare.com. Reference: 1 "Aging Statistics" posted on the Alliance for Aging Website www.agingresearch.org/aging_stats.cfm 2 J. Cid-Ruzafa, L.E. Caulfield, Y. Barron and S.K. West, Nutrient intakes and adequacy among an older population on the eastern shore of Maryland: The Salisbury Eye Evaluation, J Am Diet Assoc 9 (1999), pp. 564–571 3 C.W. Enns, J.D. Goldman and A. Cook, Trends in food and nutrient intakes by adults: NFCS 1977-78, CSFII 1989-91, and CSFII 1994-95, Fam Econ Nutr Rev 10 (1997), pp. 16–31 4 W.Y. Juan, M. Lino and P.P. Basiotis, Quality of Diets of Older Americans, Center for Nutrition Policy and Promotion, Alexandria, VA (2004) Nutrition Insight 29 5 M.S. Finke and S.J. Huston, Healthy Eating Index scores and the elderly, Fam Econ Nutr Rev 15 (2003), pp. 67–73 6 “Chronic Disease Overview” posted on the Centers for Disease Control and Prevention Website www.cdc.gov/nccdphp/overview.htm 7 E. Millen, K.W. Dodd and A.F. Subar, Use of vitamin, mineral, nonvitamin, and nonmineral supplements in the United States: The 1987, 1992, and 2000 National Health Interview Survey Results, J Am Diet Assoc 104 (2004), pp. 942–950 8 R.R. Briefel and C.L. Johnson, Secular trends in dietary intake in the United States, Annu Rev Nutr 24 (2004), pp. 401–431 9 M. Messerer, S.E. Johanasson and A. Wolk, Use of dietary supplements and natural remedies increased dramatically during the 1990s, J Intern Med 250 (2001), pp. 160–166 10 Petrella, R. J., C. N. Lattanzio, et al. (2005). "Can adoption of regular exercise later in life prevent metabolic risk for cardiovascular disease?" Diabetes Care 28(3): 694-701 11 Sebastian RS. Older Adults Who Use Vitamin/Mineral Supplements Differ from Nonusers in Nutrient Intake Adequacy and Dietary Attitudes. Jou Am Diet Assoc 2007; 107(8): 1322-1332 12 In: K.S. Tippett and Y.S. Cypel, Editors, Design and Operation: The Continuing Survey of Food Intakes by Individuals and the Diet and Health Knowledge Survey, 1994-96, US Department of Agriculture, Agriculture Research Service, Beltsville, MD (1988) Nationwide Food Surveys Report No. 96-1 13 Fortification of Foods with Folic Acid — How Much is Enough? New Eng Jou Med 2000; 342: 1442-1445 14 R.M. Russell, Factors in aging that effect the bioavailability of nutrients, J Nutr 131 (suppl 4) (2001), pp. S1359–S1361

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Soy Component Found Effective for Joint Health By Greg Arnold, DC, CSCS, September 17, 2007, abstracted from “Genistein reduces the production of proinflammatory molecules in human chondrocytes” in the September 2007 issue of Nutritional Biochemistry Arthritis is the nation’s leading cause of disability. It limits everyday activities for 16 million Americans, results in 750,000 hospitalizations and costs our healthcare system over $51 billion each year. The Center for Disease Control estimates that the number of people aged 65 or older with arthritis is projected to more than double, from 15.7 million in 2002 to 33.3 million in 2030.(1) Fortunately, a number of natural treatments are available to help maintain joint health, including glucosamine l (2) and MSM .(3) Less well-known supplements helpful to joint health are selenium ,(4) pycnogenol (5) and vitamin K ,(6) as well as pomegranate (7) and rose hips .(8) Many of these supplements and treatments are helpful for arthritis because antioxidant intake is crucial for joint health.(9) Now a new study(10) has found that increasing soy intake may be another way to help maintain joint health. Previous studies have linked falling estrogen levels to knee and hip arthritis.(11, 12, 13) Other studies have shown that plant flavonoids modulate inflammation through their effect on inflammatory enzymes .(14, 15) Researchers assessed the ability of genistein, a component of soy previously found to have healthful benefits in women,(16) to quell the inflammation of hip bone cells exposed to inflammatory proteins called LPS proteins.(17) Genistein doses used were 25, 50, and 100 micromoles per milliliter. The researchers found that genistein decreased the levels of three prominent inflammatory proteins: COX-2, Nitric Oxide, and IL-1Beta. Specifically, 100 micromoles of Genistein prevented the increases in COX-2 seen in the placebo group. Regarding Nitric Oxide, Genistein levels of 50 micromoles “reduced Nitric Oxide production significantly” compared to controls. For IL-1Beta, genistein at 100 micromoles decreased this protein by 48% compared to controls. For the researchers, “genistein can be an attractive and viable alternative therapy for treatment or prevention of OA” and “can be effective in improving the symptoms of OA in both men and women.” Greg Arnold is a Chiropractic Physician practicing in Danville, CA. You can contact Dr. Arnold directly by emailing him at mailto:PitchingDoc@msn.com or visiting his web site at www.CompleteChiropracticHealthcare.com Reference: 1 “Targeting Arthritis: Reducing Disability for 43 Million Americans” posted on the CDC Website www.cdc.gov/nccdphp/aag/aag_arthritis.htm 2 McAlindon TE. Glucosamine and Chondroitin for Treatment of Osteoarthritis: A Systematic Quality Assessment and Meta-analysis. Journal of the American Medical Association 2000; 283: 1469 – 1475 3 Kim LS. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. In Press, Corrected Proof, Available online November 23, 2005 4 American College of Rheumatology 2005 Annual Conference – San Diego, CA www.rheumatology.org/annual/index.asp 5 Schafer A. Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol). Biomed Pharm 2005;60(1): 5-9 6 Neogi T. Low vitamin K status is associated with osteoarthritis in the hand and knee. Pediatrics 2006; 54(4): 1255-1261 7 Ahmed S. Punica granatum L. Extract Inhibits IL-1(beta)-Induced Expression of Matrix Metalloproteinases by Inhibiting the Activation of MAP Kinases and NF-(kappa) B in Human Chondrocytes In Vitro. J Nutr. 2005 Sep;135(9):2096-102 8 Winther K. A powder made from seeds and shells of a rose-hip subspecies (Rosa canina) reduces symptoms of knee and hip osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial. Scandinavian Journal of Rheumatology; 34(4): 302-308 9 Pattison DJ. Dietary beta-cryptoxanthin and inflammatory polyarthritis: results from a population-based prospective study. Am J Clin Nutr. 2005 Aug;82(2):451-5 10 Hooshmand S. Genistein reduces the production of proinflammatory molecules in human chondrocytes. Jou Nutr Biochem 2007: 18(9): 609-614 11 D.T. Felson and M.C. Nevitt, The effects of estrogen on osteoarthritis, Curr Opin Rheumatol 10 (3) (1998), pp. 269–272 12 J.A. Gokhale, S.R. Frenkel and P.E. Dicesare, Estrogen and osteoarthritis, Am J Orthop 33 (2) (2004), pp. 71–80 13 F.S. Hanna, A.E. Wluka, R.J. Bell, S.R. Davis and F.M. Cicuttini, Osteoarthritis and the postmenopausal woman: epidemiological, magnetic resonance imaging, and radiological findings, Semin Arthritis Rheum 34 (3) (2004), pp. 631–636 14 A.C. Maroney, M.A. Glicksman and A.N. Basma et al., Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway, J Neurosci 18 (1) (1998), pp. 104–111 15 M.J. Laughton, P.J. Evans, M.A. Moroney, J.R. Hoult and B. Halliwell, Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives. Relationship to antioxidant activity and to iron ion-reducing ability, Biochem Pharmacol 42 (9) (1991), pp. 1673–1681 16 Piller R. Plasma enterolactone and genistein and the risk of premenopausal breast cancer. Eur J Cancer Prev. 2006 Jun;15(3):225-32 17 M. Guha and N. Mackman, LPS induction of gene expression in human monocytes, Cell Signal 13 (2) (2001), pp. 85–94 Do you have a question for us? If so please send in your questions to newsletter@herbalremedies.com We will answer all email ASAP!

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For assistance or to purchase products by phone call toll free in the USA 1-866-467- 6444 or World Wide 1-307-577-6444 or e-mail your questions to newsletter@herbalremedies.com. We will answer e-mails in the newsletter as space allows. Our Sponsors HerbalRemedies.com Get the finest all natural health products, get the best service, and low cost worldwide delivery. Enter coupon code "NL112807" when checking out to obtain discounts on your next purchase from www.HerbalRemedies.com How would you like to save $10.49 or more off your next order? You CAN by using your 5% off coupon in conjunction with our $5.49 automatic shipping discount for orders over $75. The more you order the more you save!!!