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Herbal Remedies Natural Health Newsletter, August 2008, Issue 283

Herbal Remedies August 2008 Natural Health Newsletter Issue 283 Sponsored by www.HerbalRemedies.com Toll Free for orders 1-866-467-6444 Issue Editor - Heather Bowman

Herbs - Vitamins - Minerals - Magnetics - Candles - Aromatherapy - Holiday Gifts - Bath & Beauty - Essential Oils - Natural Pet Care - Condition & Ailment Guide - Women's Health - Men's Health - Weight Loss - Health Books Mouse Study Shows Hope for Grape Extract and Mental Health - Click here for full story. Resveratrol May Help Breast Health - Click here for full story. Phosphatidylserine Helps Stress from Exercise - Click here for full story. Rabbit Study Highlights Lycopene’s Role in Heart Health - Click here for full story. Vitamin D Levels in Mom Affects Dental Health in Kids - Click here for full story. Herbal Remedies has 2 partner sites be sure to check them out as well: Magnetic Therapy Magnets , and Natural Hair Loss Remedies Be sure to check out our Overstocked clearance items! OVERSTOCKED Give your skin a natural glow with Burt's Bees Products. We are your #1 Headquarters for your complete line of Burt’s Bees Products for that all around natural glow!! Herbal Remedies has four new vendors be sure to check them out: MacroLife Naturals, Inc. , Hyland’s Homeopathic Cell Salts, Tints of Nature/ Naked Earth Permanent Organic Hair Color Products, and Burt's Bees Men's Products Products Spotlight – Feel Safe Sending your kids back to school with this gift basket? Every Student needs a care package, show your student how much you care about them with this Customizable Student Gift Basket - Ultimate Care Package - Gift $45.00 and up. The Student Gift Basket contains a few of the nessesities every student away from home will appreciate. This Basket is arranged and wrapped keeping your student in mind. Accompanied by by personal note from the giver. You Can Customize this unbelievable and unique gift basket that any student would appreciate being away from home. Consider this an herbal health insurance plan. You must add the item "Gift Basket Starter" to your shopping cart to have us create the gift basket for you. Current Event News: Don’t prison yourself from enjoying the fresh Autumn Air because of Allergies! Allergies can affect one’s quality of life and can adversely affect productivity on the job or at school. An allergy is a response by the body’s immune system to a substance that is not usually considered harmful. When a person has an allergic response, the immune system identifies the substance (allergen) as an invader and the white blood cells begin to attack it. Since the white blood cells cause more damage to the body instead of helping it, the allergic response becomes a disease in itself. Almost any substance can act as an allergen. Prepare yourself to enjoy the changing of the season by naturally protecting yourself from seasonal allergies! Check Out our Back to School Wellness Savings with our Coupon Savings and with these kind of prices you can afford to stock up! QUESTIONS AND ANSWERS Q: Subject: Hello Hi I am trying to find out about your “Children's Liquid Multi-Vitamin & Multi-Mineral formula”. I live in Kentucky , but am working with a Chinese Orphanage to get Liquid Calcium to the children. I routinely visit China for work, and have developed a great relationship with the Orphanage. The Director said that the children need Calcium, but that the only Calcium they can get in China has a very strong odor. When they mix the Calcium in their bottles the children refuse to eat it. Then they don’t eat or get their Calcium. I am wondering about your Children's Liquid Multi-Vitamin & Multi-Mineral formula. What flavor does it come in? Is it a strong odor/taste? Is it appropriate for all ages? Any suggestions would be very helpful I leave next Thursday for China , so I need to find out about your product quickly. Thank you for your time. A: Dear Customer, Here is a children's multi we carry that tastes wonderful my daughter takes it right out of the teaspoon and licks it clean it has a fruit punch flavor to it: Children’s multi-vitamin . Hope this helps and keep up the good work! All my best, Thank you for your interest in Herbal Remedies.com and the opportunity to serve you. Heather * The statements regarding these products have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. The information on this Web site or in emails is designed for educational purposes only. It is not intended to be a substitute for informed medical advice or care. You should not use this information to diagnose or treat any health problems or illnesses without consulting your pediatrician or family doctor. Please consult a doctor with any questions or concerns you might have regarding you or your child's condition. Informational material and representations have been provided by the manufacturers of the listed products. Our Sponsors Enter coupon code "NL082908" when checking out to obtain discounts on your next purchase from http://www.HerbalRemedies.com. How would you like to save $10.49 or more off your next order? You CAN by using your 5% off coupon in conjunction with our $5.49 automatic shipping discount for orders over $75. The more you order the more you save!!! All previous sales and previous sale items excluded , only one coupon code per order

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Mouse Study Shows Hope for Grape Extract and Mental Health By Greg Arnold, DC, CSCS, July 29, 2008, abstracted from “Grape-Derived Polyphenolics Prevent Aâ Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer's Disease” in the June 18, 2008 issue of the Journal of Neuroscience Alzheimer Disease (AD) is a condition that has doubled since 1980, currently affecting just under 5 million Americans, but expected to affect 16 million by 2050(1). AD currently costs our healthcare system over $100 billion each year(2). Fortunately, there are some simple ways to help maintain mental health , including eating apples(3), drinking green tea (4) fish oil (5) and vitamin E (6). Now a new study(7) has found that grape seed extract (GSPE), found previously to help with colon health(8) and blood pressure health(9) may help with mental health and AD. Previous research has shown that red wine improves mental health performance related to AD(10, 11). Building on these findings, a group of 16 mice known to have higher death rates due to brain degeneration similar to AD (called Tg2576 mice) were given either 200 mg per kg of bodyweight per day of GSPE or placebo for five months. This amount of GSPE is equivalent to a human dose of 1 gram per day using Food and Drug Administration criteria for converting drug equivalent dosages across species(12). The researchers then examined brain tissue to assess levels of proteins called “amyloid beta protein” in the brain, which is considered a “major risk factor” for the onset of AD(13). At the end of five months, the researchers found that GSPE “significantly inhibited” formation of the amyloid-beta protein, with amyloid beta protein levels that were 25% higher in the placebo group compared to the GSPE group. When looking at the area of the brain that had seen plaque buildup, GSPE resulted in plaque levels that were 49% lower than seen in the placebo group. What’s more, no decreases in liver function were observed in both groups, demonstrating the safety of 1 gram of GSPE extract per day. For the researchers, “Our study suggests that grape seed-derived polyphenolics may be useful agents to prevent or treat AD.” Greg Arnold is a Chiropractic Physician practicing in Danville, CA. You can contact Dr. Arnold directly by emailing him at mailto:PitchingDoc@msn.com or visiting his web site at http://www.completechiropractichealthcare.com/ Reference: 1 Hebert, LE; Scherr, PA; Bienias, JL; Bennett, DA; Evans, DA. “Alzheimer Disease in the U.S. Population: Prevalence Estimates Using the 2000 Census.” Archives of Neurology August 2003; 60 (8): 1119 – 1122 2 Ernst, RL; Hay, JW. “The U.S. Economic and Social Costs of Alzheimer’s Disease Revisited.” American Journal of Public Health 1994; 84(8): 1261 – 1264 3 Lee, C. Y. (2004). "Protective Effects of Quercetin and Vitamin C against Oxidative Stress-Induced Neurodegeneration." Journal of Agricultural and Food Chemistry 52: 7514-7517 4 Tan J. Green Tea Epigallocatechin-3-Gallate (EGCG) Modulates Amyloid Precursor Protein Cleavage and Reduces Cerebral Amyloidosis in Alzheimer Transgenic Mice J. Neurosci. 2005 25: 8807-8814 5 Wurtman RJ. Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally. In Press, Corrected Proof, Available online 21 April 2006 in Brain Research 6 American Academy of Neurology 60th Anniversary Annual Meeting 15 April 2008, Poster Sessions III: Aging and Dementia: Clinical II [P03.076] Vitamin E Use Is Associated with Improved Survival in an AD Cohort Authors: V. Pavlik, R. Doody, S. Rountree, E. Darby 7 Wang J. Grape-Derived Polyphenolics Prevent Aâ Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer's Disease. Journal of Neurosci 2008; 28(25):6388-6392; doi:10.1523/JNEUROSCI.0364-08.2008 8 Kaur M. Grape Seed Extract Inhibits In vitro and In vivo Growth of Human Colorectal Carcinoma Cells. Clin Cancer Res 2006 12: 6194-6202 9 ”Study Shows Grape Seed Extract May Be Effective In Reducing Blood Pressure” posted on Science Daily March 27, 2006 www.sciencedaily.com/releases/2006/03/060327084242.htm 10 Wang J, Ho L, Qin W, Rocher AB, Seror I, Humala N, Maniar K, Dolios G, Wang R, Hof PR, Pasinetti GM (2005) Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease. FASEB J 19:659–661 11 Luchsinger JA, Tang MX, Siddiqui M, Shea S, Mayeux R (2004) Alcohol intake and risk of dementia. J Am Geriatr Soc 52:540–546 12 FDA Website www.fda.gov/cber/gdlns/dose.htm 13 Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ, Rowan MJ (2005) Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat Med 11:556–56

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Resveratrol May Help Breast Health By Greg Arnold, DC, CSCS, July 30, 2008, abstracted from “Resveratrol Prevents Estrogen-DNA Adduct Formation and Neoplastic Transformation in MCF-10F Cells” in the July 2008 issue of Cancer Prevention Research As the number one killer of Americans, passing heart disease in 2005(1), nearly 1.5 million men and women (52% men 48% women) will be diagnosed with cancer , resulting in an estimated 565,650 deaths in 2008(2), and costing our healthcare system $218 billion each year(3). Breast cancer is the second biggest cancer killer of American women after lung cancer, causing an estimated 40,580 deaths in 2004(4). It is estimated to cause 213,000 new cases and nearly 41,000 deaths in 2006(5), and costs our health care system $80 to $100 billion per year(6). Fortunately, there are a number of ways to help maintain breast cell health, including lignans in pre-menopausal women( 7) and post-menopausal women(8), curcumin (9), soy (10), kelp (11), apples(12), broccoli (13), olive oil (14) exercise(15) and vitamin D (with studies in 2006(16) and 2008(17)). Now a new study18 has built upon a 2007 study(19), supporting resveratrol’s potential for breast cell health. When looking at the amount of resveratrol in wine, one glass of wine contains 174 milligrams of resveratrol(20). In the study, researchers exposed breast cells (specifically, MCF-10F cells) to increasing amounts of resveratrol from 0 to 50 micromoles per Liter. They then exposed the breast cells to a toxin called TCDD that is known to increase expression of a protein called CYP1B1 and initiate breast cancer(21). They found that with exposure to as little as 10 micromoles of resveratrol stopped TDCC-induced CYP1B1 expression in the breast cells and also helped prevent DNA damage. For the researchers, “Resveratrol may act as a potential…agent against estrogen-initiated breast cancer by blocking most of the critical steps in the estrogen [cancer-causing] pathway.” Greg Arnold is a Chiropractic Physician practicing in Danville, CA. You can contact Dr. Arnold directly by emailing him at mailto:PitchingDoc@msn.com or visiting his web site at www.CompleteChiropracticHealthcare.com Reference: 1 “Cancer passes heart disease as top killer” posted on www.nytimes.com/2005/01/20/health/20cancer.html 2 “Incidence and Mortality” posted on http://seer.cancer.gov/statfacts/html/all.html 3 “Costs of Cancer” posted on www.cancer.org/docroot/MIT/content/MIT_3_2X_Costs_of_Cancer.asp 4 "2004/2005 Fact Sheet Cancer Registries: The Foundation for Cancer Prevention and Control" posted on the CDC website http://www.cdc.gov/cancer/npcr/ 5 “Cancer Facts and Figures: 2006” posted on the American Cancer Society Website http://www.cancer.org/downloads/STT/CAFF2006PWSecured.pdf 6 Radice D. Breast cancer management: quality-of-life and cost considerations. Pharmacoeconomics 2003;21(6):383-96 7 Piller R. Plasma enterolactone and genistein and the risk of premenopausal breast cancer. Eur J Cancer Prev. 2006 Jun;15(3):225-32 8 Touillaud MS. Dietary Lignan Intake and Postmenopausal Breast Cancer Risk by Estrogen and Progesterone Receptor Status. J. Natl. Cancer Inst. 2007 99: 475-486; doi:10.1093/jnci/djk096 9 Skibola CF. Brown kelp modulates endocrine hormones in female sprague-dawley rats and in human luteinized granulosa cells. J Nutr 2005; 135(2): 296-300 10 Lampe JW. Plasma Isoflavones and Fibrocystic Breast Conditions and Breast Cancer Among Women in Shanghai, China. Cancer Epidemiol Biomarkers Prev 2007 16: 2579-2586 doi: 10.1158/1055-9965.EPI-07-0368 11 Skibola CF. Brown kelp modulates endocrine hormones in female sprague-dawley rats and in human luteinized granulosa cells. J Nutr 2005; 135(2): 296-300 12 Liu, R. H., J. Liu, et al. (2005). "Apples prevent mammary tumors in rats." J Agric Food Chem 53(6): 2341-3 13 Jackson, S.J. and K.W. Singletary, Sulforaphane inhibits human mcf-7 mammary cancer cell mitotic progression and tubulin polymerization. J Nutr, 2004. 134(9): p. 2229-36 14 Menendez, J. A. "Oleic acid, the main monounsaturated fatty acid of olive oil, suppresses Her-2/neu (erbB-2) expression and synergistically enhances the growth inhibitory effects of trastuzumab (Herceptin) in breast cancer cells with Her-2/neu oncogene amplification." Ann Oncol 16(3): 359-71 15 Chlebowski, R. T., M. Pettinger, et al. (2004). "Insulin, physical activity, andcaloric intake in postmenopausal women: breast cancer implications." J Clin Oncol 22(22): 4507-13 16 Palmieri C. Serum 25 hydroxyvitamin D levels in early and advanced breast cancer. Clin Pathol. Published Online First: 17 October 2006. doi:10.1136/jcp.2006.042747 17 Mohr SB. Relationship between Low Ultraviolet B Irradiance and Higher Breast Cancer Risk in 107 CountriesThe Breast Journal. Volume 14 Issue 3 Page 255-260 18 Lu F. Resveratrol Prevents Estrogen-DNA Adduct Formation and Neoplastic Transformation in MCF-10F Cells. Cancer Prev Res 2008 1: 135-145. doi: 10.1158/1940-6207.CAPR-08-0037 19 Tang FY. Resveratrol inhibits heregulin-â1-mediated matrix metalloproteinase-9 expression and cell invasion in human breast cancer cells. Jou Nutr Biochem 2007. In Press, Corrected Proof, Available online 24 July 2007 20 “Resveratrol” posted on http://lpi.oregonstate.edu/infocenter/phytochemicals/resveratrol/ Carnell DM, Smith RE, Daley FMTarget validation of cytochrome P450 CYP1B1 in prostate carcinoma with protein expression in associated hyperplastic and premalignant tissue. Int J Radiat Oncol Biol Phys 2004;58:500–9

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Phosphatidylserine Helps Stress from Exercise By Greg Arnold, DC, CSCS, July 29, 2008, abstracted from “The effects of phosphatidylserine on endocrine response to moderate intensity Exercise” in the 2008 issue of the Journal of the International Society of Sports Nutrition Frequently cited as “America’s #1 Health Problem”, the American Institute of Stress estimates that 75-90% of all visits to primary care physicians are for illnesses caused or made worse by stress. These include high cholesterol, high blood pressure, and heart disease (1). A recent survey(2) found that half of Americans are stressed by finances and one in three are stressed by their health and employment. Chronic psychological stress may, in fact, be so detrimental to our health that it may increase our risk for cancer (3). A number of ways have been found to deal with stress naturally. These include probiotics (4), black tea (5), and Relora , with studies done in 2005(6) and 2006(7). Now a new study(8) has found that phosphatidylserine (PS), a naturally occurring nutrient found mostly in the brain, lungs, heart, liver, and skeletal muscle(9) and shown to benefit mental health in the elderly(10) as well as young people(11) may also help with stress on the body from exercise. Previous research has shown that 750 mg of PS increases the time to exhaustion during cycling exercise(12) and improves sprint and exercise performances during exhaustive intermittent running(13). Building on these findings, ten healthy men took 600 mg of PS per day or placebo and completed cycling exercises over a 3-week period. After their maximal oxygen consumption was measured (VO2 Max), the patients exercised at 65% VO2 Max and had a 5% increase in intensity every three minutes until 85% VO2 Max was reached and cycling for a total of 15 minutes. The patients then provided blood samples over the next 65 minutes, during which cortisol , growth hormone , and testosterone levels were measured. The researchers found that PS “resulted in significantly lower” levels of cortisol at the beginning of exercise compared to placebo, reducing cortisol levels by 39%. The researchers suggest that PS plays a role in the HPA (hypothalamo-pituitary-adrenal) Axis that resulted in the lower cortisol levels. Although increased testosterone levels were seen in the PS group, statistical significance was not reached and no significant changes were seen with growth hormone. The significance of PS’s effect on lowering cortisol levels is that excessive cortisol levels have been linked to a negative training state and could lead to overtraining(14). For the researchers, “The results of this study suggest that 600 mg per day of PS might have the potential to avert an overtrained state.” Greg Arnold is a Chiropractic Physician practicing in Danville, CA. You can contact Dr. Arnold directly by emailing him at mailto:PitchingDoc@msn.com or visiting his web site at www.CompleteChiropracticHealthcare.com Reference: 1 “Stress: America’s #1 Health Problem” posted on www.rd.com/content/openContent.do?contentId=16174 2 “Americans reveal top stressors, how they cope” 3 Reiche EM. Stress and depression-induced immune dysfunction: implications for the development and progression of cancer. Int Rev Psychiatry. 2005 Dec;17(6):515-27 4 Zariei M. Probiotics prevent bacterial translocation and improve intestinal barrier function in rats following chronic psychological stress. Gut 2006; 55(11): 1553-1560 5 Steptoe A. The effects of tea on psychophysiological stress responsivity and post-stress recovery: a randomised double-blind trial. Psychopharmacology (Berl). 2006 Sep 30; [Epub ahead of print] 6 Kreiger DR. A Randomized Double Blind Placebo Controlled Clinical Trial of Relora in the Management of Stress in Healthy Overweight Females. Posted on the Natural and Nutritional Industry Products website 7 “Experimental Biology 2006” posted on the Federation of the American Society of Experimental Biology Website http://www.faseb.org/meetings/eb2006/call/ 8 Starks MA. The effects of phosphatidylserine on endocrine response to moderate intensity Exercise. Journal of the International Society of Sports Nutrition 2008, 5:11 doi:10.1186/1550-2783-5-11 9 Pepeu G, Pepeu IM, Amaducci L: A review of phosphatidylserine pharmacological and clinical effects. Is phosphatidylserine a drug for the ageing brain? Pharmacol Res 1996, 33:73-80 10 Crook TH, Tinklenberg J, Yesavage J, Petrie W, Nunzi MG, Massari DC: Effects of Phosphatidylserine in age-associated memory impairment. Neurol 1991, 41:644-649 11 Benton D, Donohoe RT, Sillance B, Nabb S: The Influence of Phosphatidylserine Supplementation on Mood and Heart Rate when Faced with an Acute Stressor. Nutr Neurosci 2001, 4(3):169-178 12 Kingsley MI, Miller M, Kilduff LP, McEneny J, Benton D: Effects of phosphatidylserine on exercise capacity during cycling in active males. Med Sci Sports Exerc 2006, 38(1):64-71 13 Kingsley MI, Wadsworth D, Kilduff LP, McEneny J, Benton D: Effects of phosphatidylserine on oxidative stress following intermittent running. Med Sci Sports Exerc 2005, 37(8):1300-1306 14 Kuipers H, Keizer HA: Overtraining and elite athletes: Review and directions for the future. Sports Med. 1988, 6:79-92

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Rabbit Study Highlights Lycopene’s Role in Heart Health By Greg Arnold, DC, CSCS, July 7, 2008, abstracted from “Comparison of lycopene and fluvastatin effects on atherosclerosis induced by a high-fat diet in rabbits” printed online June 30, 2008 in the journal Nutrition Atherosclerosis is “one of the most widespread conditions that threaten human health and survival”(1). It is characterized by damage to blood vessel walls from a number of factors, including infection, mechanical damage, and damaged LDL cholesterol that leads to an excessive chronic inflammatory response(2). It currently affects nearly 81 million Americans(3) and costs our healthcare system $6 billion each year(4). Fortunately, there are a number of healthy options to help with heart health and atherosclerosis, including fiber (5), whole grains(6), garlic (7), vitamin E (8) and vitamin K (9). Now a new study in rabbits(10) has found that lycopene , known to benefit skin health(11), prostate health (12), female health(13), and cellular health(14) may also help with inflammation and atherosclerosis. In the study, 40 adult male rabbits were fed either a standard diet or a high-fat diet (HFD). The standard diet was a breakdown of 3.5% fat, 20% protein , and 25% carbohydrate that consisted of 10% wheat, 40% grass powder, 12% soybean cake, 20% corn, 10% wheat bran, 3% fish flour, 1% salt, 3% bone meal, and 1% multivitamins. The HFD consisted of 5% lard, 1% cholesterol, and 94% standard diet. They were fed the standard diet, the HFD, the HFD plus 4 mg/kg of lycopene, the HFD plus 12 mg/kg of lycopene, or a HFD plus 10 mg/kg of fluvastatin (a prescription medication for atherosclerosis) (15) for 8 weeks. The researchers then measured blood levels of total cholesterol, total triglyceride, HDL and LDL cholesterol, total antioxidant levels, and a measure of antioxidant damage called malondialdehyde. Finally, they measured levels of an inflammatory protein called interleukin-1. While the high fat diet increased levels of LDL cholesterol and interleukin-1 by 102% and 150%, respectively, these levels were 25% and 50% lower in both lycopene groups, respectively. Both levels were unchanged in the fluvastatin group. These results are significant because LDL “has a crucial role in inducing atherosclerosis and it has been identified as an independent risk factor for coronary heart disease”(16). Interleukin-1 is “the key factor in the inflammatory reaction” that contributes to the early formation of atherosclerotic lesions”(17). Finally, measurements of artery plaque were 40% lower than the HFD and similar between both the lycopene groups and the fluvastatin group. For the researchers, “Lycopene, like fluvastatin, significantly attenuated atherogenesis in rabbits fed a high-fat diet” and that “These findings provide a theoretical rationale for the use of lycopene as a preventive and therapeutic drug in atherosclerosis.” Greg Arnold is a Chiropractic Physician practicing in Danville, CA. You can contact Dr. Arnold directly by emailing him at mailto:PitchingDoc@msn.com or visiting his web site at www.CompleteChiropracticHealthcare.com Reference: 1 Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993;362:801–9 2 Libby P. Inflammation in atherosclerosis. Nature 2002;420:868 –74 3 “Cardiovascular Disease Statistics” posted on www.americanheart.org/presenter.jhtml?identifier=4478 4 “Atherosclerosis” posted on http://ospp.od.nih.gov/pdf/atherosclerosis.pdf 5 Kan H. Dietary fiber intake and retinal vascular caliber in the Atherosclerosis Risk in Communities Study. Am. J. Clinical Nutrition, Dec 2007; 86: 1626 – 1632 6 Mellen PB. Whole-grain intake and carotid artery atherosclerosis in a multiethnic cohort: the Insulin Resistance Atherosclerosis Study. Am J Clin Nutr 2007; 85(6): 1495-1502 7 Rassoul F. The influence of garlic (Allium sativum) extract on interleukin 1á-induced expression of endothelial intercellular adhesion molecule-1 and vascular cell adhesion molecule-1. Phytomedicine 2006; 13(4): 230-235 8 Devaraj S. Effect of high-dose alpha-tocopherol supplementation on biomarkers of oxidative stress and inflammation and carotid atherosclerosis in patients with coronary artery disease. Am. J. Clinical Nutrition, Nov 2007; 86: 1392 –1398 9 Schurgers LJ. Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats. Blood 2007 Apr 1;109(7):2823-31 10 Min-Yu H. Comparison of lycopene and fluvastatin effects on atherosclerosis induced by a high-fat diet in rabbits. In Press, Corrected Proof, Available online 30 June 2008 11 Heinrich U. Antioxidant supplements improve parameters related to skin structure in humans. Skin Pharmacol Physiol. 2006;19(4):224-31 12 Limpens J. Combined Lycopene and Vitamin E Treatment Suppresses the Growth of PC-346C Human Prostate Cancer Cells in Nude Mice J. Nutr. 2006 136: 1287-1293 13 Zhao X. Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal women. American Journal of Clinical Nutrition, Vol. 83, No. 1, 163-169 14 Vrieling A. Lycopene supplementation elevates circulating insulin-like growth factor–binding protein-1 and -2 concentrations in persons at greater risk of colorectal cancer Am. J. Clinical Nutrition, Nov 2007; 86: 1456 – 1462 15 International Atherosclerosis Society. International Atherosclerosis Society harmonized guidelines on prevention of atherosclerotic cardiovascular disease. Full Report. 2003, p. 1–74. www.athero.org 16 Lamarche B, Tchernof A, Moorjani S, Cantin B, Dagenais GR, Lupien PJ, et al. Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men. Prospective results from the Quebec Cardiovascular Study. Circulation 1997;95: 69–75 17 Loppnow H, Westphal E, Buchhorn R, Wessel A, Werdan K. Interleukin-1 and related proteins in cardiovascular disease in adults and children. Shock 2001;16(suppl 1):3–9

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Vitamin D Levels in Mom Affects Dental Health in Kids By Greg Arnold, DC, CSCS, July 9, 2008, abstracted from “Mom's vitamin D during pregnancy strengthens kid's teeth” posted July 9, 2008 on FoodProductionDaily.com A mother diet’s during her pregnancy has been found to have a significant impact on the health of the newborn. Beneficial newborn nutrition includes vitamin C for immune system health (1), vitamin E to help protect against mercury(2), vitamin B-3 for nervous system development(3), calcium for bone health(4), and fish oil for eye and brain health(5). Now a new study(6), presented at the International Association of Dental Research, has found that vitamin D , which benefits bone health(7), immune system health(8), blood sugar health(9), overall health(10), prostate health (11), breast cell health (12) and mental health (13), may also help improve dental health in infants. In 2007, Americans made about 500 million visits to dentists, and an estimated $98.6 billion was spent on dental services. Cavities affect more than 25% of U.S. children aged 2–5 and half of those aged 12–15. Untreated cavities can cause pain, dysfunction, absence from school, and poor appearance—problems that can greatly affect a child’s quality of life(14). In the study, 206 pregnant women in their second trimester provided data on their dietary habits. They also gave blood samples to have their vitamin D levels measured. Researchers found that while the average vitamin D blood level was 48.1 nanomoles per liter, 34.5% of the women had levels below 35 nanomoles per liter and were classified as vitamin D-deficient. Only 10.5% of the patients had vitamin D levels above 80 nanomoles per liter and were classified as “adequate”. The National Institutes of Health classified vitamin D deficiency as being below 37.5 nanomoles per liter and ”adequate” as above 75 nanomoles per liter(15). The researchers then followed up with the infants at an average of 16 months. They found that one in three infants had early childhood cavities and the mothers of these infants had vitamin D blood levels that were, on average, 17% lower than the mothers of infants without cavities (43.9 versus 52.8 nmol/L, respectively). For the researchers, “This study shows for the first time that maternal vitamin-D levels may have an influence on…the development of early-childhood [cavities]." Greg Arnold is a Chiropractic Physician practicing in Danville, CA. You can contact Dr. Arnold directly by emailing him at mailto:PitchingDoc@msn.com or visiting his web site at www.CompleteChiropracticHealthcare.com Reference: 1 Hoppu, U., M. Rinne, et al. (2005). "Vitamin C in breast milk may reduce the risk of atopy in the infant." Eur J Clin Nutr 59(1): 123-8 2 Beyrouty P. Co-consumption of selenium and vitamin E altered the reproductive and developmental toxicity of methylmercury in rats Neurotoxicity and Teratology. Available online 19 January 2006 3 Ieraci A. Nicotinamide Protects against Ethanol-Induced Apoptotic Neurodegeneration in the Developing Mouse Brain. Public Library and Science – Medicine 2006; Volume 3 Issue 4 printed online ahead of print 4 Chan G. Effects of Dietary Calcium Intervention on Adolescent Mothers and Newborns: A Randomized Controlled Trial. Obst Gynecol 2006; 108(3, Part 1):565-571 5 Jacobson JL. Beneficial Effects of a Polyunsaturated Fatty Acid on Infant Development: Evidence from the Inuit of Arctic Quebec. Jou Ped 2008; 152: 356-364.e1 6 Schroth C. Influence of maternal vitamin D status on infant oral health. Abstract #1646 www.dentalresearch.org/i4a/pages/index.cfm?pageid=3297 7 Talwar SA. Dose response to vitamin D supplementation among postmenopausal African American women. Amer Jou Clin Nutr 2007; 86: 1657-1662 8 Martineau AR. A Single Dose of Vitamin D Enhances Immunity to Mycobacteria. Am. J. Respir. Crit. Care Med. 176: 208-213. First published online as doi:10.1164/rccm.200701-007OC 9 Hu FB. Vitamin D and Calcium Intake in Relation to Type 2 Diabetes in Women. Diabetes Care 29: 650-656 10 Autier P, Gandini S. Arch Intern Med. 2007;167(16):1730-1737 11 Bao BY. Protective role of 1, alpha-25-dihydroxyvitamin D3 against oxidative stress in nonmalignant human prostate epithelial cells. International Journal of Cancer 2008; 122(12): 2699-2706 12 Mohr SB. Relationship between Low Ultraviolet B Irradiance and Higher Breast Cancer Risk in 107 CountriesThe Breast Journal. Volume 14 Issue 3 Page 255-260 13 Witte JG. Depression Is Associated With Decreased 25-Hydroxyvitamin D and Increased Parathyroid Hormone Levels in Older Adults. Arch Gen Psychiatry. 2008;65(5):508-512 14 "Oral Health: Preventing Cavities, Gum Disease, and Tooth Loss", posed on www.cdc.gov/nccdphp/publications/AAG/doh.htm 15 “Vitamin D” posted on the National Institute’s of Health of Dietary Supplements website http://ods.od.nih.gov/factsheets/vitamind.asp Do you have a question for us? If so please send in your questions to newsletter@herbalremedies.com We will answer all email ASAP!

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